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Heterocyclic amide compound and use thereof
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
NARA, HIROSHI,KAIEDA, AKIRA,SATO, KENJIRO,TERAUCHI, JUN
申请号:
ES06822961
公开号:
ES2380236T3
申请日:
2006.10.27
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound represented by the formula ** Formula ** in which A is a zinc linking group selected from the following groups: each of them has a substituent or substituents selected from: (i) a halogen atom, ( ii) a cyano group, (iii) a hydroxy group, (iv) a nitro group, (v) a formyl group, (vi) an amino group, (vii) a mono- or di-C 1-6 alkylamino group, ( viii) a C1-6 alkylcarbonylamino group, (ix) a C1-6 alkoxycarbonylamino group, (x) a C1-6 alkyl group, (xi) a C3-8 cycloalkyl group, (xii) a C6 aryl group -14, (xiii) a C1-6 alkoxy group, (xiv) a carboxyl group, (xv) a C1-6 alkoxycarbonyl group, (xvi) a C7-16 carbonyl aralkyloxy group, (xvii) an aryloxy group C6-14-carbonyl, (xviii) a C3-8-carbonyl cycloalkyl group, (xix) a C7-16 carbonyl group, (xx) a carbamoyl group, (xxi) a thiocarbamoyl group, (xxii) a mono group - or di-C1-6-carbamoyl alkyl, (xxiii) a mono- or di-aralkyl C7-16-carbamoyl group , (xxiv) a thiol group, (xxv) a C1-6 alkylthio group, (xxvi) a C7-16 aralkyl group, (xxviii) a C3-8 cycloalkylsulfonyl group, (xxix) a C6-14 arylsulfonyl group, (xxx ) a C7-15 aralkylsulfonyl group, (xxxi) a 5- to 8-membered non-aromatic heterocyclic group containing, in addition to carbon atoms, 1 to 4 heteroatoms selected from a nitrogen atom, a sulfur atom and an atom of oxygen, (xxxii) a 5- to 8-membered aromatic heterocyclic group containing, in addition to carbon atoms, 1 to 4 heteroatoms selected from a nitrogen atom, a sulfur atom and an oxygen atom, (xxxiii) a group ureido, (xxxiv) a C1-6 alkylureido group, (xxxv) a C6-14 arylureido group, (xxxvi) a C1-6 alkoxy-C1-6 alkyl group, and (xxxvii) a mono-, di- or tri group - halogenated C1-6 alkyl, X is CZ, wherein Z is a hydrogen atom, a halogen atom or N; Y is a spacer having 2 to 10 atoms and optionally having a substituent or substituents selected from (i) a halogen atom, (ii) a cyano group, (iii) a hydroxy group, (iv) an amino group, (v) a mono- or di-C1-6 alkylamino group, (vi) a C7-16 aralkylamino group, (vii) a C1
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