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Derivatives of spiro [2.4] bridged heptane ester
专利权人:
Actelion Pharmaceuticals Ltd.
发明人:
BUR, Daniel,CORMINBOEUF, Olivier,CREN, Sylvaine,GRISOSTOMI, Corinna,LEROY, Xavier,POZZI, Davide,RICHARD-BILDSTEIN, Sylvia
申请号:
ES11824274
公开号:
ES2553635T3
申请日:
2011.11.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I) ** Formula ** in which W represents -CH2-CH2- or -CH>; = CH-; Y represents a bond or an alkanediyl (C1-C2) group; R1 represents an aryl or a heteroaryl group, whose groups are independently unsubstituted, mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, alkoxy (C1-C4), fluoroalkyl (C1-C2) and fluoroalkoxy (C1-C2); R2 represents - (C3-C6) cycloalkyl, which is unsubstituted or mono-substituted with R3R4N-CH2- or heterocyclylmethyl; or - (C2-C6) alkyl, which is - mono-substituted with -NR3R4, -C (O) NR5R6, (C1-C4) alkoxy, or (C1-C4) alkoxy which is mono-substituted with heterocyclyl, whose heterocyclyl is unsubstituted, or monosubstituted in a nitrogen atom with (C1-C4) alkyl and / or independently mono- or di-substituted in one or two of the carbon atoms with substituents independently selected from halogen and (C1-) alkyl C4); or - mono- or di-substituted with hydroxy; or - (C1-C6) alkyl, which is mono-substituted - with (C3-C6) alkyl, whose cycloalkyl is mono-substituted with -NR3R4; - with heterocyclyl, whose heterocyclyl is unsubstituted, or mono-substituted on a nitrogen atom with (C1-C4) alkyl and / or independently mono- or di-substituted on one or two of the carbon atoms with substituents independently selected in tre halogen and (C1-C4) alkyl; or - with an aryl- or heteroaryl group, whose groups are independently unsubstituted, mono-, di- or tri-substituted, in which the substituents are independently sectioned between the group consisting of halogen, (C1-C4) alkyl, -CH2NH2 and -SO2NH2; or - fluoroalkyl (C3-C6), which is mono-substituted with heterocyclyl, whose heterocyclyl is unsubstituted or independently mono- or di-substituted on one or two of the carbon atoms with substituents independently selected from halogen and alkyl (C1 -C4); or - heterocyclyl, which is unsubstituted, or mono-substituted on a nitrogen atom with alkyl (C or benzyl and
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