GlaxoSmithKline Intellectual Property Development Limited
发明人:
EIDAM, Hilary Schenck,DEMARTINO, Michael P.,GONG, Zhen,GUAN, Amy Huiping,RAHA, Kaushik,WU, Chengde,YANG, Haiying,YU, Haiyu,ZHANG, Zhiliu,CHEUNG, Mui
申请号：
ES14713598
公开号：
ES2616655T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound according to Formula (I): ** Formula ** wherein: R1 is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, hydroxyl, C1-C6 alkoxy, C1- haloalkoxy C6, C3-C6 cycloalkoxy, amino, ((C1-C6) alkyl) amino-, or ((C1-C6) alkyl) ((C1-C6) alkyl) amino-； each R2 is independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, cyano, hydroxyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkoxy, amino, (alkyl (C1-C6)) amino-, and ((C1-C6) alkyl) ((C1-C6) alkyl) amino-； R3 is 5 or 6 membered phenyl or heteroaryl, each of which is optionally substituted with one to three substituents independently selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, cyano, 5 or heteroaryl 6 members, -OR4, and -CONR5R6； wherein said C1-C6 alkyl is optionally substituted with cyano, hydroxyl, C1-C4 alkoxy, C1-C4 haloalkoxy, or -NR5R6； and wherein said 5 or 6 membered heteroaryl substituent is optionally substituted with halogen, C1-C4 alkyl, or C1-C4 haloalkyl； R4 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, or 4-6 membered heterocycloalkyl； wherein said C1-C6 alkyl is optionally substituted with cyano, hydroxyl, C1-C4 alkoxy, C1-C4 haloalkoxy, or - NR5R6； and wherein said C3-C6 cycloalkyl is optionally substituted with one or two substituents independently selected from C1-C4 alkyl, C1-C4 haloalkyl, hydroxyl, C1-C4 hydroxyalkyl, C1-C4 alkoxy, and C1-C4 haloalkoxy； and wherein said 4- to 6-membered heterocycloalkyl is optionally substituted with one or two substituents independently selected from C1-C4 alkyl and C1-C4 haloalkyl； R5 and R6 are each independently selected from the group consisting of hydrogen, C1-C4 alkyl, and C1-C4 haloalkyl； or R5 and R6 taken together with the nitrogen to which they are attached represent a saturated ring of 5 or 6 members, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, wherein said ring is optionally substituted with
