CALDARELLI, Marina,ANGIOLINI, Mauro,COLOMBO, Riccardo,DISINGRINI, Teresa,NUVOLONI, Stefano,POSTERI, Helena,SALSA, Matteo,SILVAGNI, Marco
申请号：
ES09769164
公开号：
ES2572360T3
申请日:
2009.06.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (I): ** Formula ** where R1 is an orthosubstituted aryl group or a heterocyclyl or cycloalkyl (C3-C7) group； R2 is a hydrogen atom or a (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl or straight or branched heterocyclyl group； R3 is aryl； R4 is a hydrogen atom, a hydroxyl or (C1-C6) alkyl group, this group may optionally be cyclized together with one of the atoms in the group that may represent R3 to form a fused cyclic (C4-C7) group； R5 and R6 are in each case, independently of each other, a hydrogen atom, (C1-C6) alkyl, or are optionally cycled together with the carbon atom to which they are attached to form a (C3-C7) cycloalkyl group, being "aryl" an aromatic carbocyclic or heteroaryl group containing 1 to 2 ring units, fused or linked together by simple bonds, at least one of the rings being aromatic； and comprising any aromatic heteroaryl ring (also known as aromatic heterocyclyl group), if present, a 5 to 6 member ring containing 1 to 3 heteroatoms selected from N, O or S； "orthosubstituted aryl" being an aryl group as defined above attached to the -NH- fraction, said aryl being always substituted in an ortho position, that is, on the adjacent ring atom to which it is attached to the -NH- fraction , and which is also optionally substituted in other free positions； "heterocyclyl" (also known as "heterocycloalkyl") being a 3- to 7-membered carbocyclic ring, saturated or partially unsaturated, where one or more carbon atoms have been replaced by heteroatoms such as nitrogen, oxygen and sulfur； being "cycloalkyl (C3-C7)", therefore including cycloalkyl (C4-C7), a monocyclic ring of 3 to 7 members all carbon, which may contain one or more double bonds but does not contain any electron system - fully conjugated ； where "C1-C6) is straight or branched alkyl", therefore including (C1-C4) alkyl, any of the groups such as, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert -butyl, sec-butyl, n-pentyl, n-hexy
