HUI, Hon Chung,SANGI, Michael,YANG, Hai,JANSA, Petr,MACKMAN, Richard L.,PARRISH, Jay,BOOJAMRA, Constantine G.,SIEGEL, Dustin,SPERANDIO, David
申请号：
ES12814092
公开号：
ES2647486T3
申请日:
2012.12.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula I: ** Formula ** or a salt or ester thereof； wherein: A is - (C (R4) 2) n- in which any one C (R4) 2 of said - (C (R4) 2) n- may be optionally replaced with -O-, -S- , -S (O) p-, NH or NRa； n is 3, 4, 5 or 6； each p is 1 or 2； Ar is a C2-C20 heterocyclyl group or a C6-C20 aryl group, in which the C2-C20 heterocyclyl group or the C6-C20 aryl group is optionally substituted with 1, 2, 3, 4 or R6； Each R3, R4 or R6 is independently H, oxo, OR11, NR11R12, NR11C (O) R11, NR11C (O) OR11, NR11 (O) NR11R12, N3, CN, NO2, SR11, S (O) pRa, NR11S ( O) pRa, -C (>； = O) R11, -C (>； = O) OR11, -C (>； = O) NR11R12, -C (>； = O) SR11, -S (O) p (OR11), -SO2NR11R12, -NR11S (O) p (OR11), -NR11SOpNR11R12, NR11C (>； = NR11) NR11R12, halogen, (C1-C8) alkyl, alkenyl (C2-C8), alkynyl (C2-C8), arylalkyl (C1 -C8), C6-C20 aryl, C2-C20 heterocyclyl, (C3-C7) cycloalkyl or carbocyclylalkyl (C4-C8) alkyl； or two R4 in adjacent carbon atoms, when taken together, can optionally form a double bond between the two carbons to which they are attached or can form a cycloalkyl ring (C3-C7) in which a carbon atom of said cycloalkyl ring (C3-C7) may be optionally replaced with -O-, -S-, -S (O) p-, -NH- or -NRa-； or four R4 in adjacent carbon atoms, when taken together, can optionally form an optionally substituted C6 aryl ring； or two R4 on the same carbon atom, when taken together, can optionally form a cycloalkyl ring (C3-C7) in which a carbon atom of said cycloalkyl ring (C3-C7) can be optionally replaced with - O-, -S-, -S (O) p-, -NH- or NRa-； or two R6 in adjacent carbon atoms, when taken together, can optionally form a cycloalkyl ring (C3-C7) in which a carbon atom of said cycloalkyl ring (C3-C7) can be optionally replaced with -O -, -S-, -S (O) p-, -NH- or -NRa-； each Ra is independently (C1-C8) alkyl, halo (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C1-C8) arylalkyl, C6-C20 aryl, C2-C20 heterocyclyl, cycloalkyl (C3-C7) or carbocyclylalkyl (C4-C8) alkyl in which an
