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Compounds of piperidine of the quinoxaline type substituted with azetidine and their uses
- 专利权人:
- Purdue Pharma L.P.
- 发明人:
- TAFESSE, Laykea,TSUNO, Naoki,ZHOU, Xiaoming
- 申请号：
- ES12813964
- 公开号：
- ES2583146T3
- 申请日:
- 2012.11.30
- 申请国别(地区):
- ES
- 年份:
- 2016
- 代理人:
- 摘要：
- A compound of Formula (I): ** Formula ** or a pharmaceutically acceptable derivative thereof in which: Y1 is O or S； Q is benzo or heteroaryl (5 or 6 members)； each R2 is independently selected from: (a) -halo, -CN, -NO2, -OT3, -C (>； = O) T3, -C (>； = O) OT3, -C (>； = O) N (T1 ) (T2), -S (>； = O) 2OT3, -S (>； = O) T3, -S (>； = O) 2T3, -OS (>； = O) 2T3, -S (>； = O) 2N ( T1) (T2), -N (T1) (T2), -N (T3) C (>； = O) T3, -N (T3) C (>； = O) N (T1) (T2), -N ( T3) S (>； = O) T3, -N (T3) S (>； = O) 2T3, -N (T3) C (>； = O) OT3, and -N (T3) S (>； = O) 2N ( T1) (T2)； and (b) -C1-C6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -C1-C6-alkoxy, -C3-C7-cycloalkyl, -C6-C14-cycloalkyl ), -trichloralkyl (C8-C20), -cycloalkenyl (C5-C10), -bicycloalkenyl (C7-C14), -trichloralkenyl (C8-C20), -heterocycle (5 or 6 members), and -bicycloheterocycle (7 to 10 members), each of which is not substituted or substituted with 1, 2, or 3 independently selected R8 groups； and (c) -phenyl, -naphthalenyl, -aryl (C14), or -heteroaryl (5 or 6 members), each of which is unsubstituted or substituted with 1, 2, or 3 independently selected R7 groups； a is an integer selected from 0, 1, and 2； Each R3 is independently selected from: (a) -halo, -CN, -NO2, -OT3, -C (>； = O) T3, -C (>； = O) OT3, -C (>； = O) N (T1 ) (T2), -S (>； = O) 2OT3, -S (>； = O) T3, -S (>； = O) 2T3, -OS (>； = O) 2T3, -S (>； = O) 2N ( T1) (T2), -N (T1) (T2), -N (T3) C (>； = O) T3, -N (T3) C (>； = O) N (T1) (T2), -N ( T3) S (>； = O) T3, -N (T3) S (>； = O) 2T3, -N (T3) C (>； = O) OT3, and -N (T3) S (>； = O) 2N ( T1) (T2)； and (b) -C1-C6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -C1-C6-alkoxy, -C3-C7-cycloalkyl, -C6-C14-cycloalkyl ), -trichloralkyl (C8-C20), -cycloalkenyl (C5-C10), -bicycloalkenyl (C7-C14), -trichloralkenyl (C8-C20), -heterocycle (5 or 6 members), and -bicycloheterocycle (7 to 10 members), each of which is not substituted or substituted with 1, 2, or 3 independently selected R8 gro
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- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
