BABAOGLU, Kerim,BOOJAMRA, Constantine,EISENBERG, Eugene,HUI, Hon Chung,MACKMAN, Richard,PARRISH, Jay,SANGI, Michael,SAUNDERS, Oliver,SIEGEL, Dustin,SPERANDIO, David,YANG, Hai
申请号：
ES11729018
公开号：
ES2571334T3
申请日:
2011.06.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula I or Formula II: ** Formula ** or a pharmaceutically acceptable salt or ester thereof； wherein: A is - (C (R4) 2) n- where any one C (R4) 2 of said - (C (R4) 2) n- can be optionally replaced with -O-, -S-, - S (O) p-, NH or NRa； n is 3, 4, 5 or 6； each p is 1 or 2； Ar is a C2-C20 heterocyclyl group or a C6-C20 aryl group, in which the C2-C20 heterocyclyl group or the C6-C20 aryl group are optionally substituted with 1 to 5 R6, X is -C (R13) (R14) ) -, -N (CH2R14) - or X is absent； Y is No. CR7； Each R1, R2, R3, R4, R5, R6, R7 or R8 is independently H, oxo, OR11, NR11R12, NR11C (O) R11, NR11C (O) OR11, NR11C (O) NR11R12, N3, CN, NO2, SR11, S (O) pRa, NR11S (O) pRa, -C (>； = O) R11, -C (>； = O) OR11, -C (>； = O) NR11R12, -C (>； = O) SR11, -S (O) p (OR11), -SO2NR11R12, -NR11S (O) p (OR11), -NR11SOpNR11R12, NR11C (>； = NR11) NR11R12, halogen, (C1-C8) alkyl, alkenyl (C2-C8), (C2-C8) alkynyl, (C1-C8) arylalkyl, C6-C20 aryl, C2-C20 heterocyclyl, (C3-C7) cycloalkyl or carbocyclyl (C4-C8) alkyl； two R4 in adjacent carbon atoms, when taken together, can form a double bond between the two carbons to which they are attached or can form a cycloalkyl ring (C3-C7) where a carbon atom of said cycloalkyl ring (C3 -C7) can optionally be replaced by -O-, - S-, -S (O) p-, -NH- or -NRa-； four R4 in adjacent carbon atoms, when taken together, can form an optionally substituted C6 aryl ring； two R4 in the same carbon atom, when taken together, can form a cycloalkyl ring (C3-C7) where a carbon atom of said cycloalkyl ring (C3-C7) can be replaced by -O-, -S-, -S (O) p-, -NH- or -NRa-； two R6 in adjacent carbon atoms, when taken together, can form a cycloalkyl ring (C3-C7) where a carbon atom of said cycloalkyl ring (C3-C7) can be replaced by -O-, -S-, - S (O) p-, -NH- or -NRa-； any R6 adjacent to the bound carbonyl group of said Ar, when taken together with R3, can form a bond or a group - (C (RS) 2) m- where m is 1 or 2； any R6 adjacent to the bound carbonyl
