BLANCO PILLADO MARIA JESUS,COHEN MICHAEL PHILIP,FILLA SANDRA ANN,HUDZIAK KELVIN JOHN,KOHLMAN DANIEL TIMOTHY,BENESH DANA RAE,VICTOR FRANTZ,XU YAO CHANG,YING BAI PING,ZACHERL DEANNA PIATT,ZHANG DEYI,MAT
申请号：
IN5230/KOLNP/2011
公开号：
IN2011KN05230A
申请日:
2011.12.29
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, where X is C(R3c= or -N= R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl R3a, R3b, and, when X is C(R3c)=, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen R4 is hydrogen or C1-C3 alkyl R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen R6 is hydrogen or C1-C6 alkyl and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.
