ISOQUINOLONE CYCLHEXYLAMINE DERIVATIVES AS INHIBITORS OF RHO-QUINASA.

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专利权人:

SANOFI-AVENTIS;SANOFI

发明人:

PLETTENBURG, OLIVER,HOFMEISTER, ARMIN,KADEREIT, DIETER,BRENDEL, JOACHIM,LOEHN, MATTHIAS

申请号：

ES06776307

公开号：

ES2372067T3

申请日:

2006.07.20

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

A compound of the formula (I) or of the formula (I ') in which R1 is H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, [(C1-C6) alkylene ] 0-1-cycloalkyl (C3-C8), [alkylene (C1-C6)] 0-1-heterocyclyl (C5-C10), [alkylene (C1-C6)] 0-1-aryl (C6-C10), C (O) -alkyl (C1-C6), C (O) alkenyl (C2-C6), C (O) - alkynyl (C2-C6), C (O) - [alkylene (C1-C6)] 0- 1-cycloalkyl (C3-C8), C (O) - [alkylene (C1-C6)] 0-1-heterocyclyl (C5-C10), or C (O) - [alkylene (C1-C6)] 0-1 - (C6-C10) aryl, R2 is H, (C1-C6) alkyl, [(C1-C6) alkylene] 0-1-R ', [(C1-C6) alkylene] 0-1-O-alkyl ( C1-C6), [(C1-C6) alkylene] 0-1-O-R ', [(C1-C6) alkylene] 0-1-NH2, [(C1-C6) alkylene] 0-1-NH- (C1-C6) alkyl, [(C1-C6) alkylene] 0-1-N [(C1-C6) alkyl] 2, [(C1-C6) alkylene] 0-1-CH [R '] 2, [ (C1-C6) alkylene] 0-1-C (O) -R ', [alkylene (C1-C6)] 0-1-C (O) NH2, [(C1-C6) alkylene] 0-1- C (O) NH-R ', or [(C1-C6) alkylene] 0-1-C (O) N [R'] 2； R3 is H, halogen, CN, (C1-C6) alkyl, (C1-C6) alkylene -R ', OH, O-R' ', NH2, NHR ", NR" R "or NH-C (O) - R '', R4 is H, halogen, hydroxy, CN, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C1-C6) alkylene； R5 is H, halogen, CN, NO2, alkyl ( C1-C6), alkenyl (C2-C6), R ', alkylene (C1-C6) -aryl (C6-C10), alkenylene (C2-C6) - aryl (C6-C10), alkylene (C1-C6) - heterocyclyl (C5-C10), NH2, NH-R ', NH-SO2H, NH-SO2-alkyl (C1-C6), NH-SO2-R', NHC (O) -alkyl (C1-C6), NH- C (O) -R ', C (O) N [(C1-C6) alkyl] 2, C (O) OH or C (O) O-C1 (C6) alkyl； R6 and R6' are independently of each other H, R ', (C1-C8) alkyl, (C1-C6) -R' alkylene, (C1-C6) alkylene -O-C1-C6 alkyl, (C1-C6) -O-R 'alkylene, (C1-C6) alkylene -CH [R '] 2, (C1-C6) alkylene -C (O) -R', (C1-C6) alkylene -C (O) NH2, (C1-C6) alkylene (O) NH-R 'or (C1-C6) alkylene-C (O) N [R'] 2； R7 and R8 are independently from each other H, halogen, CN, NO2, (C1-C6) alkyl, O- (C1-C6) alkyl, O- [(C1-C6) alkylene] 0-1-R ', (C2-C6) alkenyl, R', (C2-C6) alkenylene-(C6-C10) alkylene, ( C1-C6) -R ' , NH2, NH-R ', NH-SO2H, NH-SO2-alkyl (C1-C6), NH-SO2-R', SO2-NH2, SO2-NHR ',

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