A compound of the formula: wherein R1 represents hydrogen, hydroxy, or a C1-C6 alkoxy, C2-C5 alkoxycarbonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C6-C10 aryl, C5-C10 heteroaryl or C3- cycloalkyl group C8, each group is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C2-C5 alkoxycarbonyl, amino, (mono) - C1-C6 alkylamino and (di) -C1-C6 alkylamino； Y1 represents a single bond or C1-C6 alkylene； X1 represents a single bond, an oxygen or sulfur atom, sulfonyl or NR3； Z1 represents a C2-C6 alkylene or C3-C8 cycloalkylene group, each group is optionally substituted with at least one hydroxyl； X2 represents NR4； Y2 represents a single bond or C1-C6 alkylene； n is an integer 0, 1 or 2； Each R2 group independently represents halogen, cyano, S (O) mR9, OR10, SO2NR10R11, CONR10R11, NR10R11, NR10SO2R9, NR10CO2R9, NR10COR9, C6-C10 aryl, C5-C10 heteroaryl, C1-C6 alkyl, C2-C6 alkenyl C2-C6 or C3-C8 cycloalkyl, the last six groups are optionally substituted with one or more substituents independently selected from halogen, cyano, S (O) pR12, OR13, SO2NR13R14, CONR13R14, NR13R14, NR13SO2R12, NR13CO2R12, NR13COR12, C1 alkyl -C6, C1-C3 haloalkyl and C3-C8 cycloalkyl, R3 represents hydrogen or C1-C6 alkyl； R4 represents CO2R5, SO2R5, COR5, SO2NR6R7 or CONR6R7； R5 represents (i) a 3 to 8-membered saturated heterocyclic ring containing 1 or 2 ring heterogroups independently selected from NR8, S (O) or oxygen, the ring is optionally substituted with one or more substituents independently selected from halogen, hydroxyl , C1-C6 alkyl and C1-C6 alkoxy, or (ii) a C6-C10 aryl group or C5-C10 heteroaryl group, each of which may be optionally substituted with one or more substituents independently selected from halogen, cyano, alkyl C1-C6, haloalkyl C1-C3, S (O) rR9, OR10, CO2R10, SO2NR10R11, CONR10R11, NR10R11, NR10SO2R9, NR10CO2R9 and NR10COR9, or (iii) a C1-C6 alkyl group, C2-C6 a
