A compound of formula (I): ** Formula ** in which X and Z are independently selected from the group consisting of hydrogen, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl unsubstituted or substituted (C3-C8) cycloalkyl, (C3-C8) cycloalkyl-C1-C8 alkyl or unsubstituted or substituted (C2-C8) alkenyl, unsubstituted or substituted cycloalkenyl, cycloalkenyl (C5-C8) -substituted or substituted (C2-C8) -alkyl (C2-C8), unsubstituted or substituted, (C6-C10) bicycloalkyl, unsubstituted or substituted C3-C8-heterocycloalkyl, C3-C8-heterocycloalkyl- unsubstituted or substituted (C1-C8) -alkyl or -C2-C8-alkenyl, unsubstituted or substituted phenyl, unsubstituted or substituted-C2-C8-phenyl-alkyl (C2-C8), unsubstituted or substituted heteroaryl or substituted, heteroaryl-C1-C8-alkyl or unsubstituted or substituted-(C2-C8) -alkenyl, halo, cyano, -CORa, -CO2Ra, -CONRaRb, -CONRaNRaRb, -SRa, -SORa, -SO2Ra, -SO2NRaRb , nitro, - NRaRb, -NRaC (O) Rb, -NRaC (O) N RaRb, -NRaC (O) ORa, -NRaSO2Rb, -NRaSO2NRaRb, -NRaNRaRb, -NRaNRaC (O) Rb, -NRaNRaC (O) NRaRb, -NRaNRaC (O) ORa, -ORa, -OC () OC (O) NRaRb； where "substituted" means that they have from one to three substituents independently selected from acyl, C1-C6-alkyl, dimethylamino-C1-C3-alkyl, C1-C3-alkylsulfonyl, C1-C3-alkoxy, C1-C3-alkoxycarbonyl, cyano, halogen, haloalkyl, hydroxyl, oxo, amino, piperazine and nitro； Y is H or halo； R1 is (C1-C8) alkyl, (C2-C8) alkenyl, unsubstituted or substituted (C3-C8) cycloalkyl, (C3-C8) -cycloalkyl (C1-C8) -alkyl or -alkenyl (Unsubstituted or substituted) (C2-C8), unsubstituted or substituted (C5-C8) cycloalkenyl, (C5-C8) -cycloalkenyl (C1-C8) -alkyl or unsubstituted or substituted -C2-C8-alkenyl, (C6-cycloalkyl) -C10) unsubstituted or substituted, unsubstituted or substituted C3-C8 heterocycloalkyl, C3-C8-heterocycloalkyl-alkyl (C1-C8) or unsubstituted or substituted (C2-C8) alkenyl, unsubstituted or substituted phenyl, phenyl-alkyl (C1-C8) or -substituted or substituted (C2-C8) -alkenyl, unsu
