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N-(HETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF
专利权人:
SANOFI-AVENTIS
发明人:
LAURENT DUBOIS,YANNICK EVANNO,ANDRÉ MALANDA
申请号:
MYPI 20060030
公开号:
MY145932A
申请日:
2006.01.04
申请国别(地区):
MY
年份:
2012
代理人:
摘要:
THE INVENTION RELATES TO COMPOUNDS OF GENERAL FORMULA (I), WHEREIN: N IS EQUAL TO 0, 1, 2 OR 3; X1, X2, X3, X4, Z1, Z2, Z3, Z4 AND Z5 REPRESENT, INDEPENDENTLY OF EACH OTHER, A HYDROGEN OR HALOGEN ATOM OR A C1-C6-ALKYL, C3-C7-CYCLOALKYL, C3-C7-CYCLOALKYL-C1-C3-ALKYLENE, C1-C6-FLUOROALKYL, C1-C6-ALKOXY, C1-C6-FLUOROALKOXY, CYANO, C(O)NR1,R2, NITRO, NR1R2, C1-C6,-THIOALKYL, -S(O)-C1,-C6-ALKYL, -S(O)2-C1-C6-ALKYL, SO2NR1R2, NR3COR4, NR3SO2R5 OR ARYL GROUP, THE ARYL BEING OPTIONALLY SUBSTITUTED; W REPRESENTS A FUSED BICYCLIC GROUP OF FORMULA: LINKED TO THE NITROGEN ATOM VIA POSITIONS 1, 2, 3 OR 4; A REPRESENTS AN OPTIONALLY SUBSTITUTED 5- TO 7-MEMBERED HETEROCYCLE COMPRISING FROM ONE TO THREE HETEROATOMS CHOSEN FROM O, S AND N; IN THE FORM OF BASE OR OF ACID-ADDITION SALT, AND ALSO IN THE FORM OF HYDRATE OR SOLVATE. PREPARATION PROCESS AND THERAPEUTIC APPLICATION.
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