PLETTENBURG, Oliver,HOFMEISTER, Armin,LORENZ, Katrin,BRENDEL, Joachim,LÖHN, Matthias,WESTON, John
申请号：
ES07856887
公开号：
ES2625266T3
申请日:
2007.12.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (I) ** Formula ** or of the formula (I ') ** Formula ** in which R2 is H, halogen or (C1-C6) alkyl； R3 is H, halogen or (C1-C6) alkyl； R4 is H, halogen or (C1-C6) alkyl； R5 is H, halogen or (C1-C6) alkyl； R6 is H, (C1-C6) alkyl, cycloalkyl (C3-C6) or alkylene (C1-C4) -cycloalkyl (C3-C6), R6 'is H, alkyl (C1-C6), cycloalkyl (C3-C8) , heterocyclyl (C5-C10), aryl (C6-C10), alkylene (C1-C4) -cycloalkyl (C3-C8), alkylene (C1-C4) -heterocyclyl (C5-C10), alkylene (C1-C4) - aryl (C6-C10), alkylene (C1-C6) -O-alkyl (C1-C6), alkylene (C1-C6) -C (O) NH-alkyl (C1-C6), alkylene (C1-C6) - C (O) N [(C1-C6) alkyl] 2, (C1-C6) -C (O) O-alkyl (C1-C6), C (O) O-(C1-C6) alkyl, C ( O) (C1-C6) alkyl, C (O) cycloalkyl (C3-C8), C (O) NH- (C1-C6) alkyl, C (O) N [(C1-C6) alkyl] 2, C ( O) alkylene (C1-C6) -cycloalkyl (C3-C8), C (O) alkylene (C1-C6) -heterocyclyl (C5-C10), C (O) alkylene (C1-C6) -aryl (C6-C10 ), or R6 and R6 ', together with the N atom to which they are linked, form a heterocyclyl group (C5-C10)； R7 is H, halogen, (C1-C6) alkyl or O (C1-C6) alkyl； R8 is H, halogen or (C1-C4) alkyl； n is 1, 2, 3 or 4； m is 1, 3, 4 or 5； and L is O or O-alkylene (C1-C6)； wherein in the residue R6 'the aryl (C6-C10) and the heterocyclyl (C5-C10) are whether to replace or substituted one or more times with suitable groups independently selected from CONH2, CONH-alkyl (C1-C6), CON- [(C1-C6) alkyl] 2 and where, if m is 3, R6 is not H； and wherein, if m is 3 and R6 is a residue selected from (C1-C6) alkyl, cycloalkyl (C3-C6) or alkylene (C1-C4) -cycloalkyl (C3-C6), alkyl, alkylene or cycloalkyl in said residue is substituted one or more times with OH, OCH3, COOH, COOCH3, NH2, NHCH3, N (CH3) 2, CONHCH3 or CON (CH3) 2； or its stereoisomeric forms and / or its pharmaceutically acceptable salts.Un compuesto de la fórmula (I) **Fórmula** o de la fórmula (I') **Fórmula** en el que R2 es H, halógeno o alquilo (C1-C6)； R3 es H, halógeno o alquilo (C1-C6)； R4 es H, halógeno o alquilo (
