Calitor Sciences, LLC;Sunshine Lake Pharma Co., Ltd.
发明人:
XI, Ning,WU, Yanjun,LIAO, Min,FENG, Yanming
申请号：
ES13826459
公开号：
ES2634414T3
申请日:
2013.07.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, wherein: Q is -N (Rc) C (>； = O) Rd； W is CR7 or N； each of X, Y and Z is independently H, D, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C1-C4) alkylene (C3-C8) cycloalkyl, (C3-C7) heterocyclyl, -C1-C4-alkylene-C3-C7-heterocyclyl, C6-C10-aryl, 5-10-membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -alkylene ( C1-C4) -aryl (C6-C10) or -alkylene (C1-C4) - (5-10 membered heteroaryl), wherein each of the (C1-C6) alkyl, cycloalkyl (C3-C8), - (C1-C4) alkylene (C3-C8) cycloalkyl, (C3-C7) heterocyclyl, (C1-C4) -heterocyclyl (C3-C7), aryl (C6-C10), 5-10 membered heteroaryl, -C1-C4-alkylene-C6-C10-aryl and -C1-C4-alkylene- (5-10-membered heteroaryl) is unsubstituted or optionally substituted with 1, 2, 3, 4 or 5 independently selected substituents among D, F, Cl, Br, CN, (C2-C6) alkenyl, (C2-C6) alkynyl, ORa, NRaRb, - (C1-C4) alkylene -ORa and (C1-C4) -NRaRb； each of R1, R2, R3, R4, R5, R6 and R7 is independently H, D, F, Cl, Br, CN, N3, ORa, (C1-C6) alkyl, halo (C1-C6) alkyl, alkenyl ( C2-C6) or (C2-C6) alkynyl； each of Ra, Rb and Rc is independently H, aliphatic (C1-C6), haloalkyl (C1-C6), cycloalkyl (C3-C6), - alkylene (C1-C4) -cycloalkyl (C3-C6), heterocyclyl ( C3-C6), -alkylene (C1-C4) -heterocyclyl (C3-C6), aryl (C6-C10), 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -C1-C4-alkylene-C6-C10-aryl or -C1-C4-alkylene (5-10-membered heteroaryl), wherein each of the aliphatic (C1-C6), haloalkyl (C1- C6), cycloalkyl (C3-C6), -alkylene (C1-C4) -cycloalkyl (C3-C6), heterocyclyl (C3-C6), -alkylene (C1-C4) -heterocyclyl (C3-C6), aryl (C6 -C10), 5-10 membered heteroaryl, -C1-C4 alkylene-C6-C10-aryl and -C1-C4-alkylene- (5-10-membered heteroaryl) is unsubstituted or optionally substituted with 1 , 2, 3 or 4 substituents
