BALA, Kamlesh,BUTLER, Rebecca,COLLINGWOOD, Stephen,HALL, Edward,EDWARDS, Lee,LEGRAND, Darren,SPIEGEL, Katrin
申请号：
ES12783308
公开号：
ES2558457T3
申请日:
2012.09.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I ** Formula ** wherein: A is N or CR4a； X is ** Formula ** R1 is selected from H； C1-C8 alkyl optionally substituted by one or more halogen atoms； C2-C8 alkenyl； C2-C8 alkynyl； C3-C10 cycloalkyl； C5-C10 cycloalkenyl； -C1-C4 alkyl-C3-C8 cycloalkyl； C1-C8 alkoxy optionally substituted by one or more halogen atoms； halogen； SO2NR8R9； SO2R10； S-C1-C8 alkyl optionally substituted by one or more halogen atoms； S-aryl C6-C14； - (C0-C4 alkyl) -C6-C14 aryl； and heterocyclyl - (C0-C4 alkyl) - from 3 to 14 members； wherein the heterocyclyl contains at least one heteroatom selected from N, O and S； CN； NR11R12； CONR13R14； NR13SO2R15； NR13C (O) R15 and CO2R15, wherein the cycloalkyl, cycloalkenyl, aryl and heterocyclyl groups are each optionally substituted by one or more Z substituents； R2 is C1-C4 haloalkyl； R3 is H or C1-C8 alkyl optionally substituted by one or more halogen atoms； R4 is H； C1-C8 alkyl optionally substituted by one or more halogen atoms； C2-C8 alkenyl； C2-C8 alkynyl； C3-C10 cycloalkyl； C5-C10 cycloalkenyl； -C1-C4 alkyl-C3-C8 cycloalkyl； C1-C8 alkoxy optionally substituted by one or more halogen atoms； C1-C4 alkoxy-C1-C4 alkyl； C1-C8 hydroxyalkyl； OH； CN； fluorine； - (CH2) m-NR17R18； ； - (C0-C4 alkyl) -C6-C14 aryl； heterocyclyl - (C0-C4 alkyl) - from 3 to 14 members, wherein the heterocyclyl contains at least one heteroatom selected from N, O and S； or - (C0-C4 alkyl) -CO2R15, wherein the cycloalkyl, cycloalkenyl, - (C0-C4 alkyl) -C6-C14 alkyl and heterocyclyl - (C0-C4 alkyl) - groups of 3 to 14 members are each optionally substituted by one or more substituents Z； R4a is selected from H； C1-C4 alkyl optionally substituted by one or more halogen atoms； C2-C8 alkenyl； - (C0-C4 alkyl) -C6-C14 aryl； heterocyclyl - (C0-C4 alkyl) - from 3 to 14 members； C1-C8 hydroxyalkyl； halogen； - (CH2) m- NR17R18； - (C0-C4 alkyl) -CO2R15 and - (C0-C4 alkyl) -C (O) NR17R18； wherein the heterocyclyl - (C0-C4 alkyl) -C6-C14 alkyl and - (C0-C4 alkyl) - groups
