VAN NIEL, Monique Bodil,RAY, Nicholas Charles,ALCARAZ, Lilian,PANCHAL, Terry Aaron,JENNINGS, Andrew Stephen Robert,ARMANI, Elisabetta,CRIDLAND, Andrew Peter,HURLEY, Christopher
申请号：
ES12809140
公开号：
ES2612259T3
申请日:
2012.12.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which； W is NH； Cast； R1 is a group selected from (IIa) - (IIc): ** Formula ** each of R8 and R9 is independently hydrogen or C1-C6 alkyl, or R8 and R9 can form together with the nitrogen atom to which they are attached a saturated or bicyclic saturated or cyclic 5-11 membered monocyclic ring system optionally containing an additional heteroatom that is oxygen or nitrogen, said nitrogen atom being optionally substituted with C1-C6 alkyl； wherein said C1-C6 alkyl groups may be optionally substituted with a C1-C6 alkyl, C3-C6 cycloalkyl, hydroxyl or halo group； each of X1, X2, X3, X4 and X5 is independently a carbon atom, a nitrogen atom, a group - (CH) - or a group -NH-； such that each combination thereof forms an aromatic ring system； R10 is selected from a group consisting of: hydrogen, -CN, -NRARB, -N (RC) (C2-C6 alkylene) -NRARB, - N (RC) (C3-C7 cycloalkylene) -NRARB, - (C1 alkylene -C6) -NRARB, - (C3-C7 cycloalkylene) -NRARB, -O- (C2-C6 alkylene) -NRARB, -O- (C3-C7 cycloalkylene) -NRARB, -S- (C2-C6 alkylene) NRARB, -S- (C3-C7 cycloalkylene) - NRARB, -N (RC) C (O) - (C1-C6 alkylene) -NRARB, -N (RC) C (O) - (C3-C7 cycloalkylene) - NRARB, -C (O) N (RC) - (C2-C6 alkylene) -NRARB, -C (O) N (RC) - (C3-C7 cycloalkylene) -NRARB, -C (O) N (RC) - (C2-C6 alkylene) -ORD, - C (O) N (RC) - (C3-C7 cycloalkylene) -ORD, -N (RC) C (O) NRARB, -C (O) NRARB, -N (RC ) C (O) N (RC) - (C2-C6 alkylene) - NRARB, -N (RC) C (O) N (RC) - (C3-C7 cycloalkylene) -NRARB, - (C2-C6 alkylene) - ORD, - (C3-C7 cycloalkylene) -ORD, - O- (C2-C6 alkylene) -ORD, -O- (C3-C7 cycloalkylene) -ORD, -S- (C2-C6 alkylene) -ORD, -S - (C3-C7 cycloalkylene) - ORD, -N (RC) S (O) 2- (C1-C6 alkylene) -NRARB, -N (RC) S (O) 2- (C3-C7 cycloalkylene) -NRARB, -S (O) 2N (RC) - (C2-C6 alkylene) -NRARB, -S (O) 2N (RC) - (C3-C7 cycloalkylene) -NRARB, -S ( O) 2N (RC) - (C2-C6 alkylene) -ORD, - S (O) 2N (RC) - (C3-C7 cycloalkylene) -ORD, -N (RC) S (O) 2
