您的位置: 首页 > 农业专利 > 详情页

New CCR2 receptor antagonists and uses thereof
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
EBEL, HEINER,FRATTINI, SARA,GERLACH, KAI,GIOVANNINI, RICCARDO,HOENKE, CHRISTOPH,MAZZAFERRO, ROCCO,SANTAGOSTINO, MARCO,SCHEUERER, STEFAN,TAUTERMANN, CHRISTOFER,TRIESELMANN, THOMAS
申请号:
ES10796336
公开号:
ES2524829T3
申请日:
2010.12.13
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compounds according to formula (I), ** Formula ** in which R1 is a group selected from -H, -halogen, -CN, -O-C1-C4 alkyl, -C1-C4 alkyl, -CH>; = CH2, -C≡CH, - CF3, -OCF3, -OCF2H and -OCFH2; wherein R7 is a ring selected from -C3-C8 cycloalkyl, -C3-C8 heterocyclyl, -C5-C10 -aryl and -C5-C10 heteroaryl, where ring R7 is optionally substituted with one or more groups selected from -CF3, -O-CF3, -S-CF3, - CN, - C1-C6 alkyl, -C (CH3) 2-CN and -halogen, or where the R7 ring is optionally substituted with one or more groups selected from -C1 alkyl- C6, -O-C1-C6-alkyl, -C5-C10 -aryl, -C5-C10-heteroaryl, -C3-C8 -cycloalkyl, -C3-C8-heterocyclyl, -C2-C6 -alkenyl and -C2-C6 -alkyl, optionally substituted by one or more groups selected from -OH, -NH2, -C1-C3 alkyl, -O-C1-C6 alkyl, -CN, -CF3, -OCF3, halogen, -methyl and>; = O, or where the R7 ring is additionally optionally substituted bi-valent in two adjacent atoms in the ring, such that an anelated ring is formed with one or more groups selected from -C1-C6 alkylene, -C2-C6 alkenylene and -C4-C6 alkenylene in which one, two or three centers d and carbon may optionally be replaced by 1, 2 or 3 heteroatoms selected from N, O and S, the bivalent group being optionally substituted with one or more groups selected from -OH, -NH2, -C1-C3 alkyl, -O-C1-alkyl -C6, -CN, -CF3, -OCF3, halogen and>; = O; where R2 is selected from -H, -halogen, -CN, -O-C2-C4 alkyl, -C1-C4 alkyl, -CH>; = CH2, -C≡CH, -CF3, -OCF3, - OCF2H and -OCFH2 ; wherein R3 is selected from -H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -OCH3, -CF3 and -CN; in which n is 1, 2 or 3; wherein G and E are independently selected from C-H or N; In which Z is C, and R4 and R5 are independently selected from -H, -C1-C6 alkyl, -NH2, -C3-C8 cycloalkyl, -C3-C8 heterocyclyl, -C5-C10 aryl, -C5 heteroaryl- C10 and -C (O) -N (R8, R8 '), R8 and R8' being independently selected from -H and -C1-C6 alkyl, or where Z is N, and R4 represents a pair of electrons and R5 is select
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充