A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is -C(=Z)-, wherein Z is N-CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, -NH2, -CN, -OH, -O-alkyl, -O-aryl, -COOH, -COOR4, -CONHR4, -CONHCH2-aryl, -CONR4CH2-aryl, -NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -O-alkyl-OR4, -alkyl-ONO2, O-alkyl-ONO2, -OCOOR4, -O(C=O)-aryl, -CHR4OH, -CH2OH, -CH2O(C=O)-aryl, -CH2O(C=O)-R4, -CHR4O(C=O)-aryl, -CHR4O(C=O)-R4, unsaturated carboxylic ester, substituted alkynyl, -NHSO2R4, -SR4, -SO2R4, -SO2NHR4, or -SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4and R5are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, -alkyl-OR6, -alkyl-ONO2, -S(O)0-2-(alkyl-NR6R7). R1, R2andR3are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO2, or NR8R9.本揭露提供一種具有化學式(I)的化合物或其藥學上可接受鹽類。在化學式(I)中，Ar為吲唑、5-異喹啉、6-異喹啉或其N-氧化物；X為-C(=Z)-，其中Z為N-CN、NH、NR4、NCOR4、NCONR4R5、NCO-芳基、硫原子、或氧原子；Y與J獨立地為氫、C1-C6烷基、C6-C8芳基、C1-C6氨烷基、氨基、氰基、羥基、-O-烷基、-O-芳基、羧基、-COOR4、-CONHR4、-CONHCH2-芳基、-CONR4CH2-芳基、-NHCOR4、鹵素、C1-C6鹵代烷基、-烷基-OR4、-O-烷基-OR4、-烷基-ONO2、-O-烷基-ONO2、-OCOOR4、-O(C=O)-芳基、-CHR4OH、甲醇基、-CH2O(C=O)-芳基、-CH2O(C=O)-R4、-CHR4O(C=O)-芳基、-CHR4O(C=O)-R4、未飽和羧酸酯、C2-C12炔基、有取代的C2-C12炔基、-NHSO2R4、-SR4、-SO2R4、-SO2NHR4、或-SO2NR4R5，或Y與J互相鍵結形成碳環或芳香環，其中R4與R5獨立地為氫、C1-C6烷基、C6-C8芳基、有取代的C1-C6烷基、有取代的C6-C8芳基、C5-C12環烷基、C7-C12烷基芳基、-烷基-NR6R7、-烷基-OR6、-烷基-ONO2、-S(O)0-2-(烷基-NR6R7)；以及R1、R2與R3為氫、C1-C6烷基、環烷基、芳基、烷基芳基、烷基異芳基、烷基雜環基，其中上述任一基團選擇性地為一或多個羥基、ONO2、或NR8R9所取代。
