KRASUTSKY, ALEXEI,SNYDER, NANCY,WALLACE, OWEN,XU, YANPING,YORK, JEREMY
申请号：
ES07761153
公开号：
ES2378574T3
申请日:
2007.04.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound structurally represented by the formula: ** Formula ** in which R0a is halogen； R0b is -H or -halogen； R1 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens), or -CH3 (optionally substituted with one to three halogens)； R2 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens), or -CH3 (optionally substituted with one to three halogens)； R3 is -H or -halogen； R4 is -OH, -halogen, -CN, -alkyl (C1-C4) (optionally substituted with one to three halogens), -alkoxy (C1-C6) (optionally substituted with one to three halogens), -SCF3, -C (O) O-C1-C4 alkyl, -O-CH2-C (O) NH2, cycloalkyl (C3-C8), O-phenyl-C (O) O-alkyl (C1-C4), -CH2 -phenyl, -NHSO2-alkyl (C1-C4), -NHSO2-phenyl (R21) (R21), -alkyl (C1-C4) -C (O) N (R10) (R11), in which the line of strokes represents the point of attachment to position R4； R5 is -H, -halogen, -OH-, -CN, -C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -C (O) OH, -C (O) O-C1-alkyl C4), -C (O) -C1-C4 alkyl, -O-C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -SO2-C1-C4 alkyl, -N (R8) (R8), -phenyl (R21) (R21), in which the dashed line represents the point of attachment to the position indicated by R5； in which m is 1, 2 or 3； R6 is -H, -halogen, -CN, or -C1-C4 alkyl (optionally substituted with 1 to 3 halogens)； R7 is -H, -halogen, or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens)； R8 is independently at each occurrence -H, -C1-C6 alkyl (optionally substituted with 1 to 3 halogens), -C (O) -C1-C6 alkyl (optionally substituted with 1 to 3 halogens), -C (O) -C3-C8-cycloalkyl, -S (O2) -C3-C8 -cycloalkyl or -S (O2) -C1-C3-alkyl (optionally substituted with 1 to 3 halogens)； R9 is -H or -halogen； R10 and R11 are each independently -H or-(C1-C4) alkyl, or R10 and R11 taken together with the nitrogen to which they are attached form pipe ridinyl, piperazinyl, or pyrrolidinyl； and R21 is independently at each occurrence -H, -halogen, or-(C1-C3) alkyl (optionally substi
