KAHRAMAN, Mehmet,GOVEK, Steven,NAGASAWA, Johnny,SMITH, Nicholas
申请号：
ES11793115
公开号：
ES2627692T3
申请日:
2011.06.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (VI), or a pharmaceutically acceptable salt or solvate thereof: wherein, R1 is H, F, C1-C4 alkyl, or C1-C4 fluoroalkyl； R3 is H, halogen, C1-C4 alkyl, C3-C6 cycloalkyl, or C1-C4 fluoroalkyl； each R4 is independently selected from H, halogen, -CN, -OH, -OR9, -SR9, -S (>； = O) R10, -S (>； = O) 2R10, -C (>； = O) R10, - C (>； = O) OH, -C (>； = O) OR10, -C (>； = O) NHR10, -C (>； = O) N (R10) 2, substituted or unsubstituted C1-C6 alkyl, C1 fluoroalkyl -C6 substituted or unsubstituted, substituted or unsubstituted C1-C6 fluoroalkoxy, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C1-C6 heteroalkyl； each R5 is independently selected from H, halogen, -CN, -OH, -OR9, -SR9, -S (>； = O) R10, -S (>； = O) 2R10, substituted or unsubstituted C1-C6 alkyl, fluoroalkyl C1-C6 substituted or unsubstituted, substituted or unsubstituted C1-C6 fluoroalkoxy, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C1-C6 heteroalkyl； each R6 is independently selected from H, halogen, -CN, -OH, -OR9, -SR9, -S (>； = O) R10, -S (>； = O) 2R10, substituted or unsubstituted C1-C6 alkyl, fluoroalkyl C1-C6 substituted or unsubstituted, substituted or unsubstituted C1-C6 fluoroalkoxy, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C1-C6 heteroalkyl； it is azetidinyl or pyrrolidinyl； R7 is H or C1-C4 alkyl； each R8 is independently selected from F, Cl, -CN, -OH, -OR9, -SR9, -S (>； = O) R10, - S (>； = O) 2R10, substituted or unsubstituted C1-C6 alkyl, fluoroalkyl C1-C6 substituted or unsubstituted, substituted or unsubstituted C1-C6 fluoroalkoxy, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C1-C6 heteroalkyl； or 1 R8 is considered with R1 together with the intermediate atoms that join R8 to R1 to form a 5, 6 or 7 member ring； each R9 is independently selected from H, -C (>； = O) R10, -C (>； = O) OR10, -C (>； = O) NHR10, substituted or unsubsti
