A compound of Formula (I): 5 ** Formula ** wherein the designated carbon atom * is in the R or S configuration； R1 is H, C1-C6alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 cycloalkylalkyl, C1-C6haloalkyl, or gem-dialkyl of which each alkyl is C1-C4； R2 is H, halogen, -OR11, -S (O) nR12, -CN, -C (O) R12, -C (O) NR11R12, C1-C6alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6cycloalkyl , or C4-C7 cycloalkylalkyl, and wherein each of C1-C6alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C4-C7cycloalkylalkyl is optionally substituted with 1 to 3 independently selected substituents at each occurrence of these from the group consisting of C1-C3 alkyl, halogen, -CN, -OR9, -NR9R10, and phenyl which is optionally substituted 1 to 3 times with halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1 -C4 alkoxy, -CN, -OR9, or -NR9R10； R3 is an aryl selected from the group consisting of phenyl, naphthyl, indanyl, and indenyl, or a heteroaryl selected from the group consisting of pyridyl, 2-oxo-pyridin-1-yl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,2, 4-triazinyl, 1,3,5-triazinyl, furanyl, pyrrolyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2, 3-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, tetrazolyl, indolyl, isoindolyl, benzofuranyl, benzothiophenyl, indolinyl, oxoindolinyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, indazolyl, indazolyl, indazolyl, indazolyl benzooxazolyl, benzothiazolyl, benzoisoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo [1,3] dioxolyl, quinolinyl, isoquinolinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, 2,3-dihydro-benzo [1,4] dioxinyl, benzo 1,2,2, benzo 3] triazinyl, benzo [1,2,4] triazinyl, 4H-chromenyl, indolizinyl, quinolizinyl, 6aH-thieno [2,3-d] imidazolyl, 1H-pyrr olo [2,3-b] pyridinyl, imidazo [1,2-a] pyridinyl, pyrazolo [1,5-a] pyridinyl, [l, 2,4] triazolo [4,3-a] pyridinyl, [1, 2,4] triazolo [1,5-a] pyridinyl, thieno
