GRUE-SØRENSEN, Gunnar,LIANG, Xifu,HÖGBERG, Thomas,MÅNSSON, Kristoffer,VEDSØ, Per,VIFIAN, Thomas
申请号：
ES11808566
公开号：
ES2659739T3
申请日:
2011.12.22
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the general formula I ** (See formula) ** wherein R is heteroaryl which may be optionally substituted with one or more substituents independently selected from R7； or R is heterocycloalkyl or heterocycloalkenyl, wherein said heterocycloalkyl or heterocycloalkenyl are optionally substituted with one or more substituents independently selected from R8； or R is X； R7 represents halogen, cyano or hydroxyl； or R7 represents (C1-C4) alkyl, (C2-C4) -alkenyl, (C3-C7) -cycloalkyl, heterocycloalkyl, aryl, heteroaryloarylalkyl, heterocycloalkylalkyl or (C3-C7) -cycloalkylalkyl, wherein said (C1-C4 ) alkyl, (C2-C4) -alkenyl, (C3-C7) -cycloalkyl, heterocycloalkyl, aryl, heteroaryl arylalkyl, heterocycloalkylalkyl or (C3-C7) -cycloalkylalkyl are optionally substituted with one or more substituents independently selected from R9； or R7 represents -NRaCORb, -CONRaRb, -COORc, -OCORa, -ORa, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, - NRaSO2NRaRb, -NRaSO2Rb, -SO2NRaRb, -SO2Ra, -SO2Ra, -SO2Ra, -SO2Ra, -SO2Ra, -SO2Ra, NRaRb； R9 represents halogen, cyano, hydroxy, (C1-C4) alkyl, halo (C1-C4) alkyl, -NRaCORb, -COORc, -OCORa, - CONRaRb, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, -NRaSO2NRaRb, -NRaRb, -N SO2NRaRb, -SO2Ra, - S (O) Ra, -ORa, -SRa u>； = O； R8 represents halogen, cyano or hydroxyl； or R8 represents (C1-C4) alkyl, (C2-C4) alkenyl, aryl, heteroaryl, (C3-C7) -cycloalkyl or heterocycloalkyl, wherein said (C1-C4) alkyl, (C2-C4) alkenyl, aryl , heteroaryl, (C3-C7) -cycloalkyl or heterocycloalkyl are optionally substituted with one or more substituents independently selected from R10； or R8 represents -NRaCORb, -COORc, -OCORa, -CONRaRb, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, - NRaSO2NRaRb, -NRaSO2Rb, -SO2NRaRb, -SO2Ra, -S, O), -S (O) = O,>； = N-ORa, -ON>； = CRaRb, NRaRb or - C (O) N (Ra) O-Rb； R10 represents halogen, cyano, hydroxy, (C1-C4) -alkyl, (C1-C4) alkoxy, halo (C1-C4) alkyl, halo (C1-C4) alkoxy, hydroxy (C1-C4) alkyl, cyano (C1 -C4) alkyl, aryl, heteroaryl, cycloalkyl, heter
