HILPERT, Kurt,HUBLER, Francis,KIMMERLIN, Thierry,RENNEBERG, Dorte,STAMM, Simon
申请号：
ES13707053
公开号：
ES2563189T3
申请日:
2013.01.18
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), ** Formula ** in which n represents 1 or 2； X represents -N- or -N (O) -； R1 represents hydrogen or halogen； R2 represents hydrogen or methyl； and R3 represents * aryl (C1-C3) alkyl, which in the alkyl part is optionally monosubstituted with hydroxy or heterocyclyl； and that in the aryl part it is mono-, di- or trisubstituted, in which the substituents are independently selected from the group consisting of (C1-C4) alkyl, (C2-C4) alkenyl, (C3-C6) cycloalkyl, (C1-C4) alkoxy, hydroxy (C1-C3) alkyl, hydroxy (C2-C3) alkoxy, hydroxy (C2-C3) alkoxy (C1-C2) alkyl, (C1-C2) alkoxy ( C1-C2), fluoroalkyl (C1-C3), fluoroalkoxy (C1-C3), cyano, halogen and phenoxy； or * heteroaryl (C1-C3) alkyl, which in the alkyl part is monosubstituted with heterocyclyl； and that in the heteroaryl part it is mono-, di- or trisubstituted, in which the substituents are independently selected from the group consisting of (C1-C4) alkyl, cycloalkyl (C3-C6), alkoxy (C1-C4), fluoroalkyl (C1-C3) and halogen； or * cycloalkyl (C3-C7), which is monosubstituted with -C (O) NH2 or an optionally mono-, di- or trisubstituted phenyl, in which the substituents are selected from halogen； or * cycloalkyl (C5-C7), which is optionally monosubstituted with hydroxy or oxo； and which is anelated with an optionally mono-, di- or trisubstituted phenyl, in which the substituents are selected from halogen； or * cycloalkyl (C3-C7) -alkyl (C1-C3), which in the alkyl part is optionally monosubstituted with hydroxy； and that in the cycloalkyl part it is optionally disubstituted with halogen and optionally monosubstituted with hydroxy, aryl or heteroaryl, wherein the aryl or heteroaryl groups are optionally mono-, di- or trisubstituted with halogen； or a salt of said compound.Un compuesto de fórmula (I),**Fórmula** en la que n representa 1 o 2； X representa -N- o -N(O)-； R1 representa hidrógeno o halógeno； R2 representa hidrógeno o metilo； y R3 representa * aril-alquilo (C1-C3), que en la parte alqui
