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QUININE COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR MEDICAL APPLICATION
专利权人:
BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO.; LTD
发明人:
WANG Chunjing (CN),ВАН Чуньцзин (CN),WANG Junyi (CN),ВАН Цзюньи (CN),GAO Zejun (CN),ГАО Цзэцзюнь (CN)
申请号:
RU2016104437
公开号:
RU0002641285C2
申请日:
2014.07.11
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: pharmacology.SUBSTANCE: invention relates to a compound of formula Ior a pharmaceutically acceptable salt or optical isomer thereof, wherein, in formula I, n is selected from 1 to 7, R1 means C3-C7 hydrocarbyl, which may be unsubstituted or optionally substituted by halogen, alkoxy, alkoxycarbonyl, heterocyclyl or aryl; R2 is aryl or heteroaryl containing one or more heteroatoms selected from N, O or S which may be unsubstituted or optionally substituted by one or more substituents of halogen, phenyl, -OR6, -SR6, -NR6R7, -NHCOR6, -CONR6R7, -CN, -NO2, -COOR6, -CF3 or linear or branched C1-C4 hydrocarbyl, R6 and R7 can denote a hydrogen atom or linear or branched C1-C4 hydrocarbyl; R3 is hydroxyl, halogen, alkoxy or acyloxy. Alkoxy or acyloxy may be unsubstituted or optionally substituted by halogen, hydroxyl, alkoxy, hydrocarbyl, alkoxyhydrocarbyl, heterocyclyl or aryl; R4 and R5 may or may not be present, and, independently, can mean, without limitation, a substituent such as halogen, hydroxyl, alkoxy, hydrocarbyl, alkoxyhydrocarbyl, heterocyclyl or aryl when these radicals are present. Y is linear or branched C1-C7 alkyl or - (CH2-O-CH2)m-, which may be optionally substituted by halogen, hydroxyl, alkoxy, alkoxyalkyl, unsaturated hydrocarbyl, cyclic hydrocarbyl or heterocyclyl. M is 1-3; X- means an acid residue or hydroxyl, the said compounds having a selective antagonistic effect on the M1 and M3 receptors subtypes, but insignificantly affect the M2 receptor subtype.EFFECT: compound application efficiency increase.24 cl, 5 tbl, 33 exИзобретение относится к соединению формулы I:или его фармацевтически приемлемые соль или оптический изомер, где в формуле I: n выбран из 1-7, R1 обозначает С3-С7 гидрокарбил, который может быть незамещенным или необязательно замещенным галогеном, алкокси, алкоксикарбонилом, гетероциклилом или арилом; R2 обозначает арил или гетероарил, содержащий один или более гетероатомов, выбранных из N, О или S, который может быть незамещенн
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