LIZOS, DIMITROS,WEILER, SVEN,STIEFL, NIKOLAUS JOHANNES
申请号：
ES08775322
公开号：
ES2375425T3
申请日:
2008.07.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I in free or salt or solvate form, wherein R 1 is an aryl or heterocyclyl, R 1 is optionally substituted by one or more R 3 groups independently selected from: hydroxy, carbonyl, aminocarbonyl, C 1 -C 7 alkylaminocarbonyl, amino , C1-C7 alkylamino, C1-C7 alkylthio, sulfonylamino, carbonylamino, C1-C7 alkylcarbonylamino, halo, carboxy, C1-C7 alkoxy, benzyloxy, C1-C7 alkoxycarbonyl, aminosulfonyl, C1-C7 alkyl, cyano, sulfonyl, sulfanyl, sulfoxide , aryl, heterocyclyl, carbonyloxy, amino C1-C7 alkyl, C1-C7 alkylamino-C1-C7 alkyl, aryl-C1-C7 alkyl and heterocyclyl-C1-C7 alkyl, C4-C15 cycloalkenyl and C2-C8 cycloalkynyl； and when R3 includes two groups, such R3 groups can be joined together to form a ring which merges with R1； wherein R3 is optionally substituted by one or more groups selected from hydroxyl, C1-C7 alkyl, aryl, amino, C1-C7 alkylamino, heterocyclyl, cyano, halo, sulfonyl, sulfanyl, sulfoxide, di (C1-C7) alkylamino, hydroxyloalkyl C1-C7, alkoxy, di-C1-C7 alkylamino-C1-C7 alkyl； R2 is an aryl, heteroaryl, heteroaryl-aryl, heteroaryl-heterocyclyl, aryl-heterocyclyl, biaryl, heterocyclylheterocyclyl； R2 which is optionally substituted by one or more R4 groups independently selected from aryl, heteroaryl, heterocycloalkyl, C1-C7 alkyl, C3-C10 cycloalkyl, aminocarbonyl, C1-C7 alkylaminocarbonyl, halo, C1-C7 alkoxy, C1-C7 alkylthio, hydroxyl , C1-C7 alkylcarbonyl, carboxy, carbonyl, cyano, sulfonamide and from C4-C15 cycloalkenyl； and when R4 includes two groups, such R4 groups can be joined together to form a ring which merges with R2； wherein R4 is optionally substituted by one or more groups selected from hydroxyl, C1-C7 alkyl, aryl, amino, C1-C7 alkylamino, heterocyclyl, cyano, halo, sulfonyl, sulfanyl, sulfoxide； R5 is H or NH2； wherein C1-C7 alkyl, when mentioned indicates a straight, branched or cyclic chain alkyl containing one to seven carbon atoms； and wherein heterocyclyl refers to a heteroaryl or heterocycloalkylUn compuesto de
