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Stable tablet containing a 4,5-epoxymorphinan derivative
专利权人:
Toray Industries; Inc.
发明人:
OHTA, Kotoe,TAKAKI, Suguru,HORIUCHI, Yasuhide
申请号:
ES09822078
公开号:
ES2660001T3
申请日:
2009.10.23
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Tablet comprising the following components (1) to (4): (1) as an effective ingredient, a 4,5-epoxymorphinan derivative represented by the formula (I): ** (See formula) ** [in which, the double line composed of a dotted line and a solid line represents a double bond or a single link; R1 represents C1-C5 alkyl, C4-C7 cycloalkylalkyl, C5-C7 cycloalkenyl alkyl, C6-C12 aryl, C7-C13 aralkyl, C4-C7 alkenyl, allyl, furan-2-C1-C5 alkyl or thiophene-2-C1-alkyl C5; R2 represents hydrogen, hydroxy, nitro, C1-C5 alkanoyloxy, C1-C5 alkoxy, C1-C5 alkyl or -NR7R8; R7 represents hydrogen or C1-C5 alkyl; R8 represents hydrogen, C1-C5 alkyl or -C (>; = O) R9; R9 represents hydrogen, phenyl or C1-C5 alkyl; R3 represents hydrogen, hydroxy, C1-C5 alkanoyloxy or C1-C5 alkoxy; A represents -N (R4) C (>; = X) -, -N (R4) C (>; = X) Y-, -N (R4) - or -N (R4) SO2- (where X and Y independently represent NR4, S or O; R4 represents hydrogen, C1-C5 linear or branched alkyl or C6-C12 aryl; and R4 in the formula may be the same or different); B represents a linear or branched C1-C14 alkylene or valence bond (provided that the alkylene is optionally substituted with at least one substituent selected from the group comprising C1-C5 alkoxy, C1-C5 alkanoyloxy, hydroxy, fluorine , chlorine, bromine, iodine, amino, nitro, cyano, trifluoromethyl, trifluoromethoxy and phenoxy, and that 1 to 3 methylene groups may be substituted by one or more carbonyl groups), C2-C14 linear or branched acyclic unsaturated hydrocarbon containing 1 to 3 double bonds and / or triple bonds (with the proviso that said acyclic unsaturated hydrocarbon is optionally substituted with at least one substituent selected from the group comprising C1-C5 alkoxy, C1-C5 alkanoyloxy, hydroxy, fluorine, chlorine, bromine, iodine, amino, nitro, cyano, trifluoromethyl, trifluoromethoxy and phenoxy, and that 1 to 3 methylene groups may be substituted by one or more carbonyl groups) or linear or branched saturated or unsaturated hydrocarbon
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