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Azol derivative
专利权人:
Ltd.;Taisho Pharmaceutical Co.
发明人:
YOSHINAGA, Mitsukane,KUWADA, Takeshi,MIYAKOSHI, Naoki,ISHIZAKA, Tomoko,WAKASUGI, Daisuke,SHIROKAWA, Shin-ichi,HATTORI, Nobutaka,SHIMAZAKI, Youichi
申请号:
ES12843663
公开号:
ES2568882T3
申请日:
2012.10.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
An azol derivative represented by Formula (I): ** Formula ** R1 represents a hydrogen atom, C1-C5 alkyl (C1-C5 alkyl is optionally substituted with one to three groups selected from the group consisting of hydroxy, halogen, cyano, C3-C7 cycloalkyl, and C1-C5 alkoxy), C3-C7 cycloalkyl, or 4-8 membered saturated heterocycle atoms; R2 represents a hydrogen atom or C1-C5 alkyl; R3 represents aryl or heteroaryl (aryl and heteroaryl are optionally substituted with one or two groups selected from the group consisting of C1-C5 alkoxy, C1-C5 alkyl, halogen atoms, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, difluoromethoxy, and (C1-C5) alkyl sulfonyl); R4 and R5 which may be the same or different each represent a hydrogen atom, C1-C5 alkyl (C1-C5 alkyl is optionally substituted with one to three groups selected from the group consisting of hydroxy, halogen, cyano, cycloalkyl atoms C3-C7, and C1-C5 alkoxy), C3-C7 cycloalkyl, or a saturated or unsaturated 4-8 membered heterocycle containing one or more nitrogen, oxygen or sulfur atoms in the ring (the 4-8 membered heterocycle saturated or unsaturated is optionally substituted with one or two groups selected from the group consisting of hydroxy, C1-C5 alkyl, C1-C5 alkoxy, halogen atoms, cyano, C2-C5 alkanoyl, and trifluoromethyl), or R4 and R5, together with the adjacent nitrogen atom, they form a saturated or unsaturated 4-8 membered heterocycle optionally containing one or more nitrogen, oxygen or sulfur atoms in the ring in addition to the adjacent nitrogen atom (the saturated 4-8 membered heterocycle or unsaturated is t optionally substituted with one or two groups selected from the group consisting of hydroxy, C1-C5 alkyl (C1-C5 alkyl is optionally substituted with one or two hydroxyl groups), C1-C5 alkoxy, halogen atoms, cyano, C2 alkanoyl -C5, oxo, aminocarbonyl, mono (C1-C5) aminocarbonyl, dialkyl (C1-C5) aminocarbonyl, trifluoromethyl, amino, mono (C1-C5) amino, dialkyl (C1-C5) amino and alkanoyl (C2-C5) amino ,
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