Alberto ORTEGA-MUNOS,Альберто ОРТЕГА-МУНЬОС,KHulio KASTRO-PALOMINO-LARIYA,Хулио КАСТРО-ПАЛОМИНО-ЛАРИЯ,Mattyu Kolin Tor FAJF,Маттью Колин Тор ФАЙФ
申请号：
RU2012148758/04
公开号：
RU0002599248C2
申请日:
2011.04.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: present invention relates to novel compounds of formula (1) or pharmaceutically acceptable salts thereof having inhibitory effect on LSD1 (lysin-specific demethylase-1 inhibitors). Said activity enables their use for treating or preventing some diseases such as cancer. Above cancer is selected from the group including breast cancer, colorectal cancer, lung cancer, prostate cancer, testicular cancer, cerebral cancer, skin cancer and blood cancer. In compounds of formula 1,(A) denotes a pyridyl or phenyl each (A′), if conained, is independently selected from a group consisting of phenyl, phenyl-C1-C4-alkoxy group, phenyl-C1-C4-alkyl, halogen, C1-C4-alkoxy group and halogen-C1-C4-alkyl, where each (A′) contains 0, 1, 2 or 3 substitutes independently selected from a group comprising halogen, halogen-C1-C4-alkyl, phenyl, C1-C4-alkyl and C1-C4-alkoxy group X equals to 0, 1 or 2 (B) denotes cyclopropyl ring, where (A) and (Z) covalently connected with different carbon atoms in (B) (Z) denotes -NH- (L) is selected from rhe group including a single link, -CH2-, -CH2CH2-, -CH2CH2CH2- and -CH2CH2CH2CH2- and (D) denotes C3-C7-cycloalkyl or benzo-C5-C7-cycloalkyl, where said C3-C7-cycloalkyl or said petrol-C5-C7-cycloalkyl, contains 0, 1, 2 or 3 substitutes independently selected from the group, including -NH2, halogen, amido group, C1-C4-alkoxy group and halogen-C1-C4-alkyl or its pharmaceutically acceptable salt. Compound, which is substituted with heteroarylcyclopropylamine or substituted arylcyclopropylamine and correponds to formula 2,where (R3) is present or is not, if (R3) is present, it is selected from the group consisting of phenyl-C1-C4-alkyl and phenyl-C1-C4-alkoxy group, where the said group (R3) contains 0, 1, 2 or 3 substitutes independently selected from the group including halogen, C1-C4-alkyl, C1-C4-alkoxy group, halogen-C1-C4-alkyl and phenyl (W) denotes phenyl or pyridyl group, where the said (W) contains 0, 1 or 2 substitutes sele
