您的位置: 首页 > 农业专利 > 详情页

6- (3-aza-bicyclo [3.1.0] hex-3-yl) -2-phenyl-pyrimidines as ADP receptor antagonists
专利权人:
Actelion Pharmaceuticals Ltd.
发明人:
CAROFF, Eva,HILPERT, Kurt,HUBLER, Francis,MEYER, Emmanuel,RENNEBERG, Dorte
申请号:
ES10715600
公开号:
ES2567311T3
申请日:
2010.04.07
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula I ** Formula ** in which R1 represents phenyl that is unsubstituted or mono, di or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl and fluoroalkyl (C1-C3); Z represents hydrogen, (C1-C4) alkyl, cyclopropyl, cyclopropylmethyl, hydroxy (C1-C3) alkyl, carboxyalkyl (C1-C3), cyano-C1-C3 alkyl, P (O) (R6) 2-alkyl (C1-C3), 1H-tetrazol-5-yl-C1-C3 alkyl or benzyl; R2 represents cyano, -COO-, -CONH2, -COOR3, hydroxy (C1-C3) alkyl, (C1-C2) alkoxy (C1-C2) alkyl, carboxy10 (C1-C3) alkyl, 1H-tetrazol-5 -yl or -N-R5; with the proviso that, if R2 represents -COOR3, Z represents carboxy-(C1-C3) alkyl or P (O) (R6) 2-(C1-C3) alkyl; Ra represents hydrogen or methyl; R3 represents (C1-C4) alkyl; R4 represents (C1-C6) alkoxy or benzyloxy; R5 represents hydrogen or tert-butoxycarbonyl; R6 represents hydroxy, (C1-C4) alkoxy, R7-OCH2O- or R8-(C1-C4) -NH- alkyl; R7 represents (C1-C4) alkylcarbonyl or (C1-C4) alkoxycarbonyl; and R8 represents (C1-C4) alkoxycarbonyl; or a salt of said compound.Un compuesto de fórmula I**Fórmula** en la que R1 representa fenilo que está no sustituido o mono, di o tri-sustituido, en el que los sustituyentes se seleccionan independientemente del grupo que consiste en halógeno, alquilo (C1-C4) y fluoroalquilo (C1-C3); Z representa hidrógeno, alquilo (C1-C4), ciclopropilo, ciclopropilmetilo, hidroxi-alquilo (C1-C3), carboxialquilo (C1-C3), ciano-alquilo (C1-C3), P(O)(R6)2-alquilo (C1-C3), 1H-tetrazol-5-il-alquilo (C1-C3) o bencilo; R2 representa ciano, -COO-, -CONH2, -COOR3, hidroxi-alquilo (C1-C3), alcoxi (C1-C2)-alquilo (C1-C2), carboxi10 alquilo (C1-C3), 1H-tetrazol-5-ilo o -N-R5; con la condición que, si R2 representa -COOR3, Z representa carboxi-alquilo (C1-C3) o P(O)(R6)2-alquilo (C1-C3); Ra representa hidrógeno o metilo; R3 representa alquilo (C1-C4); R4 representa alcoxi (C1-C6) o benciloxi; R5 representa hidrógeno o terc-butoxicarbonilo; R6 representa hidroxi,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充