A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer, or tautomer thereof, wherein X is halogen； Z1 and Z2 are CR2； Z3 is CH； each R1 is independently and individually halogen, H, C1-C6 alkyl, branched C3-C7 alkyl, C3-C7 cycloalkyl, or -CN； each R2 is individually and independently H, halogen, C1-C6 alkyl, or cyano； R3 is -C (O) R4, -C (O) -C6-C10 aryl, -C (O) -C4-C6 heterocyclyl, or -C (O) -C5-C6 heteroaryl, wherein aryl is phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl； and with the proviso that when R3 is -C (O) -C4-C6 heterocyclyl, the heterocyclyl does not have a point of attachment of N to -C (O)； R4 is C3-C8 cycloalkyl, C1-C7 alkyl, - (CH2) p-CN, - (CH2) p-OR6, - (CH2) p-NR6 (R7), - (CH2) p-SO2-C1-alkyl C6, - (CH2) p-aryl C6-C10, - (CH2) p-heteroaryl C5-C6, or - (CH2) p-heterocyclyl C4-C6, in which each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyl； and aryl is phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl； each R6 and R7 is individually and independently H, C1-C6 alkyl, or branched C3-C8 alkyl； each cycloalkyl, aryl, heteroaryl and heterocyclyl is independently substituted with - - (R25) m； each R25 is individually and independently C1-C6 alkyl, branched C3-C8 alkyl, halogen, - (CH2) m-CN, - (CH2) m-OR6, - (CH2) m-NR6 (R7), - (CH2) m-SO2-C1-C6 alkyl, - (CH2) mC (O) NR6 (R7), - (CH2) mC (O-heterocyclyl C4-C6, or - (CH2) m-heterocyclyl C4-C6, wherein each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyl； each m is individually and independently 0, 1, 2 or 3； and p is 1, 2 or 3.Un compuesto de Fórmula I, o una sal, enantiómero, estereoisómero, o tautómero farmacéuticamente aceptable del mismo, en la que X es halógeno； Z1 y Z2 son CR2； Z3 es CH； cada R1 es independiente e individualmente halógeno, H, alquilo C1-C6, alquilo C3-C7 ramificado, cicloalquilo C3- C7, o -CN； cada R2 es individual e independientemente H, halógeno, alquilo C1-C6, o ciano； R3 es -C(O)
