ALLWEIN, SHAWN P.,MORTON, GEORGE C.,ROSSE, GERARD C.,WANG, YI
申请号：
ES10801042
公开号：
ES2523766T3
申请日:
2010.12.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the structure of formula II ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R3 is selected from H, (C1-C6) alkyl, hydroxyalkyl (C1-C6), haloalkyl (C1- C6), (C1-C6) alkyl (C1-C6) alkoxy, CO-(C1-C6) alkyl, CONH-(C1-C6) alkyl, CO2-(C1-C6) alkyl, SO2-(C1-C6) alkyl ), SO2NH-(C1-C6) alkyl, CO-aryl (C6-C10), CONH-aryl (C6-C10), CO2-aryl (C6-C10), SO2-aryl (C6-C10), SO2NH-aryl (C6-C10), aryl (C6-C10), alkyl (C1-C6) aryl (C6-C10), cycloalkyl (C3-C10), CO-cycloalkyl (C3-C10), CONH-cycloalkyl (C3-C10) , CO2-cycloalkyl (C3-C10), SO2-cycloalkyl (C3-C10), SO2NH-cycloalkyl (C3-C10), alkyl (C1-C6) cycloalkyl (C3-C10), CO-alkyl (C1-C6) cycloalkyl (C3-C10), CONH-(C1-C6) alkyl cycloalkyl (C3-C10), CO2-alkyl (C1-C6) -cycloalkyl (C3-C10), SO2-alkyl (C1-C6) -cycloalkyl (C3- C10), SO2NH-alkyl (C1-C6) cycloalkyl (C3-C10), heterocycloalkyl (C2-C9), alkyl (C1-C6) heterocycloalkyl (C2-C9), CONH-alkyl (C1-C6) he tert-cycloalkyl (C2-C9), CO-alkyl (C1-C6) heterocycloalkyl (C2-C9), CO2-alkyl (C1-C6) heterocycloalkyl (C2-C9), SO2-alkyl (C1-C6) heterocycloalkyl (C2-C9) ), SO2NH-(C1-C6) alkyl heterocycloalkyl (C2-C9), heteroaryl (C5-C9), CO-heteroaryl (C5-C9), CONH30 heteroaryl (C5-C9), CO2-heteroaryl (C5-C9), SO2-heteroaryl (C5-C9), SO2NH-heteroaryl (C5-C9), alkyl (C1-C6) heteroaryl (C5-C9), CO-alkyl (C1-C6) -heteroaryl (C5-C9), CONH-alkyl (C1-C6) -heteroaryl (C5-C9), SO2-alkyl (C1-C6) -heteroaryl (C5-C9), SO2NH-alkyl (C1-C6) heteroaryl (C5-C9) and CO2-alkyl (C1- C6) heteroaryl (C5-C9), in which any of the above, except H, is optionally substituted with one or more substituents and provided that heteroaryl (C5-C9) is not 1,3,4-triazole optionally substituted in any of (C1-C6) alkyl (C5-C9) heteroaryl, CO-(C1-C6) -heteroaryl (C5-C9), CONH-(C1-C6) alkyl heteroaryl (C5-C9) and CO2-alkyl ( C1-C6) heteroaryl (C5-C9)； Y is CH2 or O； X is absent, O, NR4 or (C1-C4) alkyl； R4 is H or (C1-C6) alkyl； m is 1 or 2； and Z is selected from cycloalkyl (C3-C10), alkyl (C1-C6)
