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Benzylphenylcyclohexane derivatives and methods of their use
专利权人:
ТЕРАКОС; ИНК. (US)
发明人:
ЧЭНЬ Юаньвэй (US),ПЭН Кунь (CN),ЧЖАН Лили (CN),ЛВ Бинхуа (CN),СЮЙ Байхуа (CN),ДОНГ Цзяцзя (CN),ДУ Цзиюань (CN),ФЭН Янь (US),СЮЙ Гэ (CN),РАЙЯППАН Васантакумар (US),СИД Брайан (US)
申请号:
RU2010128940/13
公开号:
RU2010128940A
申请日:
2008.12.11
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The compound of formula I:! ! where! A is selected from the group consisting of oxygen, NH, methylene and a single bond; ! Q is selected from the group consisting of structures Q1-Q4; ! ! ! Z is selected from the group consisting of oxygen, sulfur, SO, SO2, 1,1-cyclopropylene, carbonyl and methylene, optionally substituted with one or two substituents independently selected from halogen, hydroxy group, C1-C6 alkyl, C1- C6 alkoxy groups, C3-C6 cycloalkyl and C3-C6 cycloalkyloxy groups; ! R1, R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, hydroxy group, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl , C1-C6 alkyloxy groups, C3-C10 cycloalkyloxy groups, cyano, amino and nitro groups, the alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or parts being optionally partially or completely fluorinated and mono- or disubstituted with the same or different substituents selected from the group consisting of chlorine, hydroxy group, C1-C3 alkoxy group s and C1-C3-alkyl, and in cycloalkyl and cycloalkenyl groups or parts one or two methylene groups, if necessary, are independently replaced by NRa, O, S, CO, SO or SO2, and one or two methine groups are replaced by N if necessary or if R1 and R2 are bonded to two adjacent carbon atoms of the phenyl ring, R1 and R2 are optionally connected to each other, so that together they form a C3-C5 alkylene, C3-C5 alkenylene or butadienylene bridge, which, if necessary partially or fully fluorinated and mono- or disubstituted the same or different substituents selected from chlorine, hydroxy group, C1-C3-�1. Соединение формулы I: ! ! где ! А выбирают из группы, состоящей из кислорода, NH, метилена и одинарной связи; ! Q выбирают из группы, состоящей из структур Q1-Q4; ! ! ! Z выбирают из группы, состоящей из кислорода, серы, SO, SO2, 1,1-циклопропилена, карбонила и метилена, при необходимости замещенных одним или двумя заместителями, не
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