GOHIMUKKULA, DEVI REDDY,JONES, DAVID,QABAJA, GHASSAN,ZHU, JEFF JIQUN,COOPER, JEREMY T.,BANNER, WILLIAM KENNETH,SUNDERMANN, KURT,BONDLELA, MURALIDHAR,RAO, MOHAN,WANG, PINGZHEN,GOWDA, RAJU BORE,ANDREWS,
申请号：
ES11745116
公开号：
ES2550667T3
申请日:
2011.02.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula (I) or a pharmaceutically acceptable salt thereof, ** Formula ** in which W is C-R6, and X and Y are N, and R6 is -H； R1, R2, R4 and R5 are independently selected from the group consisting of -H, -halogen, -ciano, -NO2, -OR9, -SR9, -S (O) sR9, -S (O) 2OR9, -S (O) sNR9R10, -NR9S (O) 2R10, -NHC (O) NHR9, - NR9C (O) R10, - (CR11R12) tNR9R10, -C (O) R9, -C (O) OR9, -C (O ) O (CR11R12) tCONR9R10, -C (O) NR9R10, -alkyl (C1-C10), - alkenyl (C2-C10), -alkynyl (C2-C10), -phenyl, -cycloalkyl (C3-C10), - pyrazolyl, -isoxazolyl, -tetrazolyl, -oxazolyl, -dihydro-oxazolyl, in which the alkyl, alkenyl, phenyl, cycloalkyl, pyrazolyl, isoxazolyl, tetrazolyl, oxazolyl and dihydro-oxazolyl groups are optionally substituted one or more times with selected substituents independently from R39, wherein R9 and R10 are independently selected from the group consisting of -H, -C1-C6 alkyl, -C3-C10-cycloalkyl, -phenyl, -C1-C6-alkylene-cycloalkyl (C3-C10), and -C1-C6 alkylene-phenyl, in which the alkyl, alkylene, cycloalkyl, phenyl groups of R9 and R10 are optionally substituted used one or more times with substituents independently selected from R39, or R9 and R10 together with the atoms to which they are attached form a 5- to 7-membered heterocyclic ring containing 0 to 2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen , and the ring is optionally substituted one or more times with substituents independently selected from R39, and R11 and R12 are independently selected from the group consisting of -H, -C1-C6 alkyl, -C3-C10 cycloalkyl, -phenyl, -C1-C6-alkylene-C3-C10-cycloalkyl, and -C1-C6-alkyl-phenyl, in which the alkyl, alkylene, cycloalkyl, phenyl groups of R11 and R12 are optionally substituted one or more times with substituents independently selected from R39, or R11 and R12 together with the carbon to which they are attached form a ring of 5 to 7 members containing 0 to 2 heteroatoms independently selected from oxygen, az ufre and ni
