BACON, EDWARD R.,BAILEY, THOMAS R.,DUNN, DEREK D.,HOSTETLER, GREG A.,MCHUGH, ROBERT J.,MORTON, GEORGE C.,ROSSE, GERARD C.,SALVINO, JOSEPH M.,SUNDAR, BABU G.,TRIPATHY, RABINDRANATH
申请号：
ES10799203
公开号：
ES2539382T3
申请日:
2010.12.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula II ** Formula ** or a salt thereof, in which: A is - (CR9R10) n- and n is 1, 2 or 3 and R9 and R10 at each occurrence are independently selected from H or alkyl ( C1-C6) unsubstituted or haloalkyl (C1-C6)； R1 at each occurrence is independently selected from H, halogen, CN, NO2, NR11R12, COR13, CO2R13, alkyl (C1-C6), haloalkyl (C1-C6), alkyl (C1-C6) -alkoxy (C1-C6), (C1-C6) alkyl-haloalkoxy (C1-C6), cycloalkyl (C3-C10), to the (C1-C6) -cycloalkyl (C3-C10), aryl (C6-C10), alkyl (C1-C6) - aryl (C6-C10), heterocycloalkyl (C2-C9), alkyl (C1-C6) -heterocycloalkyl (C2-C9), heteroaryl (C5-C9) and alkyl (C1-C6) - heteroaryl (C5-C9), and W is 0, 1, 2 or 3, in which any of the above, except H, halogen, CN and NO2, is optionally substituted with one or more substituents； R2 is selected from H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkyl (C1-C6) alkoxy, CO-(C1-C6) alkyl, CO2-(C1-C6) alkyl ), CO-aryl (C6-C10), CO2-aryl (C6-C10), aryl (C6-C10), alkyl (C1-C6) -aryl (C6-C10), cycloalkyl (C3-C10), CO- cycloalkyl (C3-C10), CO2-cycloalkyl (C3-C10), alkyl (C1-C6) -cycloalkyl (C3-C10), CO-alkyl (C1-C6) -cycloalkyl (C3-C10), CO2-alkyl ( C1-C6) -cycloalkyl (C3-C10), heterocycloalkyl (C2-C9), alkyl (C1-C6) -heterocycloalkyl (C2-C9), CO-alkyl (C1-C6) -heterocycloalkyl (C2-C9), CO2 - (C1-C6) alkyl - heterocycloalkyl (C2-C9), heteroaryl (C5-C9), CO-heteroaryl (C5-C9), CO2-heteroaryl (C5-C9), alkyl (C1-C6) -heteroaryl (C5 -C9), CO-(C1-C6) alkyl-heteroaryl (C5-C9) and CO2-alkyl (C1-C6) -heteroaryl (C5-C9), in which any of the above, except H, is optionally substituted with one or more substituents； R3 and R4 are each independently selected from H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, amino (C1-C6) -alkyl, (C1-C6) haloalkoxy, alkyl ( C1-C6) -alkoxy (C1-C6), alkyl (C1-C6) -NR13CO-alkyl (C1-C6), alkyl (C1-C6) -CON (R13) 2, aryl (C6-C10), aryloxy ( C6-C10), (C1-C6) alkyl-(C6-C10) alkyl, (C1-C6) alkyl - C6-C10 aryloxy, (C3-C10) cycloalkyl, (C3-C6) cycloalkylo
