The heat induced maceration leading to increased lycopene content of whole tomato [18.30 mg/l00g] as a modified standard procedure and formulated recipe to develop lycopene. proteins and vitamins rich synergistic health beverage justifiable for its nutraceutical potential emerged out is a success story of this investigation. The health beverage formulated by using standard whey fruit juice base and 10 per cent tomato puree reported its superiority on the basis of relative score of sensorial quality parameters and recorded 1.83 mg/100ml bioactive lycopene as a nutraceutical. The therapeutic value of whey beverage as a synergic contributory action of predominant ingredients especially tomato lycopene, whey proteins and mango vitamin C justifying therapeutic efficacy is confirmed on the basis of animal clinical studies and accordingly provided an open option for future human clinical studies.