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PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES
专利权人:
NABRIVA THERAPEUTICS GMBH
发明人:
Rosemarie Mang,Werner Heilmayer,Rudolf Badegruber,Dirk Strickmann,Rodger Novak,Mathias Ferencic,Atchyuta Rama Chandra Murty Bulusu
申请号:
US16593449
公开号:
US20200030335A1
申请日:
2019.10.04
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2′;, and if m=1 then R3 is on position 1′;); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or —;(C3-6)cycloalkyl, or —;unsubstituted (C1-6)alkyl, or —;(C1-6)alkyl substituted by one or more of —;hydroxy; preferably one or two, —;methoxy, —;halogen, —;(C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e.g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or —;with the proviso that R3 is bound to 2′; R3 represents —;O—;(CH2)P—;O—; with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.
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