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PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES
专利权人:
NABRIVA THERAPEUTICS AG
发明人:
MANG ROSEMARIE,HEILMAYER WERNER,BADEGRUBER RUDOLF,STRICKMANN DIRK,NOVAK RODGER,FERENCIC MATHIAS,BULUSU ATCHYUTA RAMA CHANDRA MURTY
申请号:
MYPI 20093722
公开号:
MY148916A
申请日:
2008.03.19
申请国别(地区):
MY
年份:
2013
代理人:
摘要:
A COMPOUND OF FORMULA (I) WHEREIN N IS 0 TO 4; M IS 0 OR 1 WITH THE PROVISO THAT THE SULPHUR ATOM AND R₃ ARE IN VICINAL POSITION (IF M = 0 THEN R₃ IS IN POSITION 2’, AND IF M = 1 THEN R₃ IS ON POSITION 1’); R IS ETHYL OR VINYL; R₁ IS HYDROGEN OR (C₁-₆)ALKYL, R₂ IS HYDROGEN OR -(C₃-₆)CYCLOALKYL, OR -UNSUBSTITUTED (C₁-₆)ALKYL, OR -(C₁-₆)ALKYL SUBSTITUTED BY ONE OR MORE OF -HYDROXY; PREFERABLY ONE OR TWO, -METHOXY, -HALOGEN, (C₃-₆)CYCLOALKYL, OR R₁ AND R₂ TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A 5 TO 7 MEMBERED HETEROCYCLIC RING CONTAINING AT LEAST 1 NITROGEN ATOM OR 1 NITROGEN AND 1 ADDITIONAL HETEROATOME E. G. SELECTED FROM N OR 0, OR R₁ IS HYDROXY AND R₂IS FORMYL; R₃ IS OH, OR₄, A HALOGEN ATOM, OR -WITH THE PROVISO THAT R₃ IS BOUND TO 2' R₃ REPRESENTS -0-(CH₂)p-0- WITH P IS 2 OR 3; R₄ IS UNSUBSTITUTED (C₁-₆)ALKYL OR (C₃-₆)CYCLOALKYL.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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