The present invention provides a pharmaceutical composition containing the following compound having antiviral action:P is hydrogen or a group to form a prodrug； A1is CR1AR1B, S or O； A2is CR2AR2B, S or O； A3is CR3AR3B, S or O； A4is each independently CR4AR4B, S or O； the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1and carbon atom adjacent to A4, is 1 or 2； R1Aand R1Bare each independently hydrogen, halogen, alkyl, or the like； R2Aand R2Bare each independently hydrogen, halogen, alkyl, or the like； R3Aand R3Bare each independently hydrogen, halogen, alkyl, or the like； R4 Aand R4Bare each independently hydrogen, halogen, alkyl, or the like； R3Aand R3Bmay be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle； R1is fluorine； m is any integer of 1 to 2； and n is any integer of 1 to 2.本發明提供一種含有具有抗病毒作用之以下化合物之醫藥組合物。P為氫原子或形成前體之基； A1為CR1AR1B、S或O； A2為CR2AR2B、S或O； A3為CR3AR3B、S或O； A4分別獨立為CR4AR4B、S或O； 此處，由A1、A2、A3、A4、與A1鄰接之氮原子、及與A4鄰接之碳原子所構成之環之成環原子之雜原子之數為1個或2個； R1A及R1B分別獨立為氫、鹵素、或烷基等； R2A及R2B分別獨立為氫、鹵素、或烷基等； R3A及R3B分別獨立為氫、鹵素、或烷基等； R4A及R4B分別獨立為氫、鹵素、或烷基等； R3A及R3B可一起形成非芳香族碳環或非芳香族雜環； R1為氟原子； m為1～2之整數； n為1～2之整數)
