Novel heterocyclic derivatives and their use in the treatment of neurological disorders

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专利权人:

Novartis AG

发明人:

BADIGER, Sangamesh,CHEBROLU, Murali,HURTH, Konstanze,JACQUIER, Sébastien,LUEOEND, Rainer Martin,MACHAUER, Rainer,RUEEGER, Heinrich,TINTELNOT-BLOMLEY, Marina,VEENSTRA, Siem Jacob,VOEGTLE, Markus

申请号：

ES12700390

公开号：

ES2576182T3

申请日:

2012.01.11

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

A compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein X1 is CR1 or N； X3 is CR3 or N； X4 is CR4 or N； X5 is CR5； where one and no more than one of X1, X3 and X4 is N； R1 is hydrogen； R2 is an aryl, heteroaryl or non-aromatic heterocyclyl group G1, whose group G1 is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group, consisting of cyano, amino, amino (C1-8) alkyl, N -C 1-4 alkyl-C 1-8 alkyl, N, N-C 1-4 alkyl-amino C 1-8 alkyl, aminocarbonyl, thiocarbamoyl, halogen, C 1-8 alkyl, halogen (C1-8) alkyl, hydroxy, oxo, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, C1-8 alkylthio halogen, (C1-8) alkoxy (C1-8), (C3-8) cycloalkyl (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkoxy； (C1-8) alkoxy-(C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), alkynyl (C2-8), alkenoxy (C2-8), alkyloxy (C2-8) and a cycloalkyl (C3-8), aryl, heteroaryl or non-aromatic heterocyclyl group G2, whose group G2 is optionally substituted by 1, 2, 3, or 4 substituents independently selected from the group, consisting of cyano, aminocarbonyl, halogen, (C 1-8) alkyl, halogen (C 1-8) alkyl, hydroxy, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen (C1-8) alkyl, (C1-8) alkoxy (C1-8) alkyl, (C1-) alkoxy 8) -alkoxy (C1-8), alkoxy (C1-8) -alkylthio (C1-8), alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8) ), (C1-8) alkylthio (C1-8) alkylthio (C2-8) alkenyl and (C2-8) alkynyl； R3 is hydrogen； R4 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C1-8), halogen-alkoxy (C1-8), alkylthio (C1-8), halogen-alkylthio (C1-8) a, (C1-8) alkoxy-(C1-8) alkyl, (C1-8) alkoxy-C1-8 alkoxy, (C1-8) alkoxy-(C1-8) alkylthio alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8)； R5 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C

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