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Quinazolinona type compounds as antagonists of crth
专利权人:
MERCK SHARP & DOHME CORP.;SCHERING CORPORATION
发明人:
申请号:
ARP110103734
公开号:
AR083367A1
申请日:
2011.10.11
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
Compounds, pharmaceutical ingredients, and processes for processing these compounds. 1. Help to treat chronic and acute allergic immune disorders: compound of formula (1) or acceptable salt of medicine in formula, where x is O-S (or) m -;And it is selected from the group consisting of: a) a link, -O-,- en...-N (R9) - o -N (COR9) -(b) Other formulas (2);(c) Other formula (3);(d) Other formula (4);(e) Other formula (5);If you are already registered, please log in first.-S- o -N (R) -This is... C.-N-;A 0, 1, 2 or 3; R is 0, 1 or 2; s is 0, 1 or 2; R is h, tar or halo tar; RA is independent h, halo, tar or halo tar; Rb is independent h, halo, tar or halo tar; R1 is heterogeneous, isopropene or isopropene; R2 is arilo, isopropene, isopropene, isopropyl or isopropene; R3 is - C (o) Oh o-n (H) - so2-rc; In the case that RC is asphalt, halogen tar, cyclopentadiene, arilo or isopropene; R4 is selected independently from asphalt Oh, halo, Alcoy, haloxy CN and halogen tar group; R8 is selected independently from group consisting of - CN, halo, tar, haloquilo, alcox, haloxy or cyclopentadiene; R9 is asphalt, Halogen, alcoxi,Among them: (1) the heteromorphic, isomerized or isomerized group in R1; and (2) each arilo, isomerized, tar or isomerized group R2 in R2; not replaced or replaced by 1 to 5 R5 groups selected from tar and alquenilo groups respectively, Asphalt, cyclopentadiene, cyclopentadiene, isopropene, isopropene, arilo, isopropene, halo, CN, sF5, osp5, NO2, ch2osi (R14) (R15) (R16),-OR14, -C (O) R14, -C (O) OR14, -O-C (O) -R14, -O-C (O) N (R14) (R15),-C (O) N (R14) (R15)-S (O) mR14 -S (O) pN (R14) (R15)- C (3DNOR14) R15 -N (R14) (R15)-N (R14) C (O) R15, -N (R14) S (O) pR15, -N (R14) S (O) pN (R15) (R16),-N (R14) C (O) N (R15) (R16) and -N (R14) C (O) OR16; or when a position is disubstituted with two R5 groups, the two R5 groups can form a cycloalkyl or heterocyclyl ring that is unsubstituted or substituted with 1 to 5 R6 groups and in which each of the alkyl, alkenyl,
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