CARVALHO MEIRELES, LIDIO MARX,THOMSON, STEPHEN ANDREW,SHETH, URVI JAGDISHBHAI,SHAW, DAVID,SCHMIDT, YVONNE,HURLEY, DENNIS,HADIDA RUAH, SARA SABINA,FANNING, LEV TYLER DEWEY,CAMP, JOANNE LOUISE,ASGIAN, I
申请号：
ARP180101925
公开号：
AR113095A1
申请日:
2018.07.11
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
Compounds and salts that can be used as inhibitors of sodium channels are acceptable on drugs. In addition, pharmaceutical compounds, including pharmaceutically acceptable compounds or salts, and methods of using these compounds, pharmaceutically acceptable salts, and pharmaceutical compounds for the treatment of various disorders (including pain) of Cha are also provided. 1. Characteristic requirement 1: formula (1) or a compound acceptable for its drug, wherein L is O, C (R) 832222, or simple link； x8309a is n or cr83099；X8310 is n or cr8310；X ° 8311 is n or Cr ° 8311；X8313es n or cr8313；X1°8304es N o Cr°830404；X1 is n or CR1；a. Each R is an independent h or C 832183318326；H RR 74919, halo, oh, rent c833218331832626；Halogenated tar c83321531832626,a.Alcox C8321218C833316O Haloalcoxi C8321218833126；r3°74919 es H，Halo，oh，OJ C83218331832626；Halogenated tar c83321531832626,a.Alcox C8321218C833316O Haloalcoxi C8321218833126；R8308；]Halogenated tar c83321531832626,a.Alcox C8321218C833316O Haloalcoxi C8321218833126；R83099,R8310 and r8311 are defined as follows: (I) r830909；R8310a and r8311a are h, halo, CN, oh, c832188316262, respectively；Halogenated tar c83321531832626,Alcoxi C832188331636262；Haloalcoxy C83218C833316A3；1.C83218331I8326A-Amino O-W-（CH832222）-8345；-R695A；(II) r8309es h, halo, CN, oh, lease c83321833183226；Halogenated tar c83321531832626,Alcoxi C832188331636262；Haloalcoxy C83218C833316A3；1.C83218331C8326-Amino o o-W-（Ch832225）；-R695y R8310y R8311；They combine with carbon atoms to form a formula ring (4)；O (III) r83099 and r8310；They combine with carbon atoms to form a formula ring (5)；R8311es h, halo, CN, oh, let c833218331832626；Halogenated tar c83321531832626,Alcoxi C832188331636262；a. Halogenated alcoxi c83217c83316o-w - (ch832222) - 8345； - r695e；R83122ES H-O-（CH83222）-8345；-R695；R8313,R83041 and R1 are independent h, halo, CN, oh, okilo c8332183316326；Halogenated tar c83321531832626,Alcoxi C832188331636262；a. Halogenated alcoxi c83217c83316o-w - (ch832
