MICHEL MAILLARD,IGNACIO MUOZ,CELIA DOMINGUEZ,CHRISTOPHER A. LUCKHURST,IAN F. HAUGHAN,GILLES RAPHY,REBECCA E. JARVIS
申请号：
ARP140101055
公开号：
AR095351A1
申请日:
2014.03.14
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
1. Claim 1: a formula compound (1),Or any pharmaceutically acceptable salts thereof, characterized by: R1 from C (o) NH (OH) and - n (OH) C (o) r8308；R2 is arilo, isopropene and isopropyl propene, each of which can be replaced by 1 to 3 independent halogen, tar, cyclopentadiene, halogen tar, hydroxy, alcoxi and nitrogen substitutes； X is deficient, or X is selected from - O -.-No. 8310-y - [C (r8311； r831222)] 8346； -；R 3 selects hydrogen, tar, cyclopentyl, isocyclopentyl, arilo, hetero, aralquilo and hetero alkenyl, each of which can be replaced by one to three independent halogen substitutes, - conr7495； - r758080；1. Asphalt, 1-n7495； - r758080；Cycloquilo, halo tar, hydroxy, Alcoy, halo alcoxi, alcoxi replaced by - nr7495；]a. Arilo, allomorphic arilo and nitilo； r83088 is selected from hydrogen, low tar and halo low tar； r83099 is selected each time, independent of halogen, low tar, halo tar and hydrogen； or R3 considered together with r83099；and any intermediate atoms, form a 3-7 membered heterocycloalkyl or cycloalkyl ring； m and m are independently selected from 1, 2 and 3, with the proviso that m + m £ 4； n is selected from 0, 1, 2 and 3； p is selected from 1 and 2； R⁶ is selected from hydrogen, lower alkyl, cycloalkyl, and halogen-lower alkyl； and each time R aparecen and R⁸ are each independently selected from hydrogen, halogen, lower alkyl, and halogen-lower alkyl, Rᵇ is selected from H, C₁₋₆ alkyl,aryl and heteroaryl； and Rᶜ is selected from hydrogen and C₁₋₄ alkyl；O r74955 and r758080；The nitrogen they attach forms a non cyclopropyl group, r74958 and r75808,each C₁₋₆ alkyl,1. C833213124 independent asphalt substitute or one or more asphalt substitutes to replace cyclopropyl, arillo, isopropyl and isopropyl；cycloalkyl C₃₋₆,1. Arilo, heatarilo, aril - (rent c832131)heteroaryl- (C₁₋₄-alkyl) -,2. Halogen-c83218c8324a1；-O-alkyl C₁₋₄,-O (C₁₋₄-alkyl) phenyl, - (C₁₋₄-alkyl) -OH, - (C₁₋₄-alkyl) -O- (C₁₋₄-alkyl),-O-halogen-c8332124a；-Oh, nh832222,- (C₁₋₄ alkyl) -NH
