THOMAS, ABRAHAM,GOPALAN, BALASUBRAMANIAN,LINGAM, PRASADA RAO V. S.,SHAH, DAISY MANISH
申请号：
CA2583457
公开号：
CA2583457C
申请日:
2005.07.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to novel compounds useful as dipeptidylpeptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)m, -CH2-, CHF, or -CF2； m is 0, 1, or 2； X is a bond, C1-C5 alkyl (e.g., -CH2-), or -C(=0)-； the dotted line [----] in the carbocyclic ring represents an optionaldouble bond； R1 is substituted or unsubstituted cycloalkyl, substituted orunsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl,substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl,substituted or unsubstituted heteroaryl, substituted or unsubstitutedheterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substitutedor unsubstituted heteroarylalkyl, CN, -COOR3, CONR3R4, -OR3, -NR3R4, orNR3COR3； R2 is hydrogen, cyano, COOH, or an isostere of a carboxylic acid(such as SO3H, CONOH, B(OH)2, PO3R3R4, SO2NR3R4, tetrazole, -COOR3, -CONR3R4,NR3COR4, or -COOCOR3).
