JAGEROVIC, NADINE,CUMELLA-MONTANCHEZ, JOSE MARIA,GOYA-LAZA, MARIA PILAR,DORDAL ZUERAS, ALBERTO,CUBERES-ALTISENT, MARIA ROSA
申请号：
ES07847122
公开号：
ES2453497T3
申请日:
2007.11.07
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Use of a compound of formula I: ** Formula ** in which: R1, R2 and R3 are independently selected from hydrogen, halogen, hydroxyl, alkoxy, substituted or unsubstituted C1-C6 alkyl, cyano, NRaRb, NHCONRc, NHSO2Rd , COOH, COORe, in which Ra is hydrogen or C1-C6 alkyl and Rb, Rc, Rd and Re are independently a C1-C6 alkyl； R4 is selected from hydrogen, C1-C6 alkyl, cycloalkyl, heterocyclyl and heteroaryl； R5 and R6 are independently a C1-C6 alkyl or form, together with the nitrogen atom to which they are attached, a substituted or unsubstituted heterocyclyl group； X is selected from -S-, -SO-, -SO2- and O； and n is an integer selected from 1, 2, 3, 4, 5, 6, 7 and 8, or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, in the manufacture of a medicament for the treatment or prophylaxis of a condition or disease selected from diarrhea, lipoprotein disorders, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, migraine, arthritis, hypertension, arrhythmia, ulcer, glaucoma, learning deficit, memory and attention, cognitive disorders, neurodegenerative diseases, demyelinating diseases, addiction to drugs and chemicals including cocaine, amphetamines, ethanol and nicotine； tardive dyskinesia, ischemic stroke, epilepsy, stroke, stress, cancer, psychotic states, in particular depression, anxiety or schizophrenia； inflammation or autoimmune diseases； and painUso de un compuesto de fórmula I:**Fórmula** en la que: R1, R2 y R3 se seleccionan independientemente de hidrógeno, halógeno, hidroxilo, alcoxilo, alquilo C1-C6 sustituido o no sustituido, ciano, NRaRb, NHCONRc, NHSO2Rd, COOH, COORe, en los que Ra es hidrógeno o alquilo C1-C6 y Rb, Rc, Rd y Re son independientemente un alquilo C1-C6； R4 se selecciona de hidrógeno, alquilo C1-C6, cicloalquilo, heterociclilo y heteroarilo； R5 y R6 son independientemente un alquilo C1-C6 o forman, junto con el átomo de nitrógeno al que están unidos, un grupo heterociclilo sustituido o no sustituido； X se sele
