The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I):wherein R1 is optionally substituted C1-C8 alkyl and the like； R2 is C1-C6 alkyl； R3 is C1-C6 alkyl and the like； or R2 and R3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring； R4 is hydrogen and the like； G is a group selected from the groups shown by the formula an the like:wherein R5 is hydrogen and the like； X1 is a single bond and the like； X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R6)—, wherein R6 is hydrogen and the like, and the like； X3 is a single bond and the like；a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.
