WHITTEN, Jeffrey P.,PEI, Yazhong,CAO, Jianguo,WANG, Zhijun,ROGERS, Evan,DYCK, Brian,GREY, Jonathan
申请号：
ES11777791
公开号：
ES2591004T3
申请日:
2011.04.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula (VI): ** Formula ** where: ** Formula ** L2 is -NH-C (>； = O) -, or -C (>； = O) NH-； X is CR3 or N； And it is independently selected from CR9 or N； R2 is C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, C2-C8 heterocycloalkyl, C1-C4 alkyleneC2-C8 heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl； wherein C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, C2-C8 heterocycloalkyl, C1-C4 alkyleneC2-C8 heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl is optionally substituted with at least one R3； R3 is independently selected from H, F, D, Cl, Br, I, -CN, -NO2, -OH, -CF3, -OCF3, -OR5, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, C2-C8 heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, n is an integer selected from 0-2； R9 is independently selected from H, D, halogen, C1-C6 alkyl, C1-C6 haloalkyl, -OR5, -OCF3, C1-C6 carbonylalkyl, or -CF3； or two R9 attached to the same carbon atom form an oxetane ring； R10 is selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, -OR5, -OCF3, C1-C6 carbonylalkyl, or - CF3； R5 is independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, phenyl and benzyl； or a pharmaceutically acceptable salt, or a pharmaceutically acceptable solvate thereof.Un compuesto de Fórmula (VI):**Fórmula** donde:**Fórmula** L2 es -NH-C(>；=O)-, o -C(>；=O)NH-； X es CR3 o N； Y se selecciona independientemente entre CR9 o N； R2 es alquilo C1-C6, heteroalquilo C1-C6, haloalquilo C1-C6, heterocicloalquilo C2-C8, alquilenC1- C4heterocicloalquiloC2-C8, arilo, heteroarilo, arilo fusionado o heteroarilo fusionado； donde alquilo C1-C6, heteroalquilo C1-C6, haloalquilo C1-C6, heterocicloalquilo C2-C8, alquilenC1-C4heterocicloalquiloC2-C8, arilo, heteroarilo, arilo fusionado o heteroarilo fusionado es opcionalmente sustituido con por lo menos un R3； R3 se selecciona independientemente entre H, F, D, Cl, Br, I, -C
