BUTLER, THOMAS,CHO, AESOP,KIM, CHOUNG U.,SAUNDERS, OLIVER L.,ZHANG, LIJUN,PARRISH, JAY
申请号：
ES09734175
公开号：
ES2536193T3
申请日:
2009.04.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof； wherein: each R1, R2, R3, R4 or R5 is independently H, ORa, N (Ra) 2, N3, CN, NO2, S (O) nRa, halogen, (C1-C8) alkyl, carbocyclylalkyl (C4) -C8), substituted (C1-C8) alkyl, substituted (C2-C8) alkenyl, substituted (C2-C8) alkenyl, (C2-C8) alkynyl, substituted (C2-C8) alkynyl or (C1-C8) alkyl ； or any two R1, R2, R3, R4 or R5 in adjacent carbon atoms when taken together are -O (CO) O- or when taken together with the ring carbon atoms to which they are attached form a double bond ； R6 is ORa, N (Ra) 2, N3, CN, NO2, S (O) nRa, -C (>； = O) R11, -C (>； = O) OR11, -C (>； = O) NR11R12, - C (>； = O) SR11, -S (O) R11, -S (O) 2R11, -S (O) (OR11), -S (O) 2 (OR11), -SO2NR11R12, halogen, (C1-) alkyl C8), carbocyclylalkyl (C4-C8) alkyl, substituted (C1-C8) alkyl, alkenyl (C2-C8), substituted alkenyl (C2-C8), alkynyl (C2-C8), substituted alkynyl (C2-C8) or aryl- (C1-C8) or R6 alkyl and any of R1 or R2 when taken together are -O (CO) O-； each n is independently 0, 1 or 2； each Ra is independently H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, aryl (C1-C8) alkyl, carbocyclyl (C4-C8) alkyl, -C (>； = O) R11, -C (>； = O) OR11, -C (>； = O) NR11R12, -C (>； = O) SR11, -S (O) R11, -S (O) 2R11, -S (O) (OR11 ), -S (O) 2 (OR11) or -SO2NR11R12； R7 is H, -C (>； = O) R11, -C (>； = O) OR11, -C (>； = O) NR11R12, -C (>； = O) SR11, -S (O) R11, -S ( O) 2R11, -S (O) (OR11), -S (O) 2 (OR11), -SO2NR11R12 or ** Formula ** each of Y or Y1 is, independently, O, S, NR, + N ( O) (R), N (OR), + N (O) (OR) or N-NR2； W1 and W2, when taken together, are -Y3 (C (Ry) 2) 3Y3-； or one of W1 or W2 together with any of R3 or R4 is -Y3- and the other of W1 or W2 is Formula Ia； or each of W1 and W2 is, independently, a group of Formula Ia: ** Formula ** in which: each Y2 is independently a bond, O, CR2, NR, + N (O) (R), N (OR), +30 N (O) (OR), N-NR2, S, SS, S (O) or S (O) 2； each Y3 is independently O, S or
