СОНДЕРЗ Джеффри О. (US),САЛИТУРО Франческо Дж. (US),ЯНЬ Шуньци (US)
申请号：
RU2012102922/04
公开号：
RU2012102922A
申请日:
2010.06.29
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein W, X, Y, and Z are independently selected from CH or N； D and D are independently selected from a bond or NR； A is an optionally substituted bicyclic heteroaryl； L is a bond, —C ( O) -, - (CRR) -, -OC (O) -, - (CRR) -OC (O) -, - (CRR) -C (O) -, -NRC (S) -, or -NRC ( O) -； R is selected from alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl； each of which is replaced by a 0-5 occurrence of R； each R is independently selected from halo, haloalkyl, alkyl, hydroxyl and -OR or two adjacent R together with carbon atoms to which they are attached, form a non-binding fully substituted cyclic； each R is independently selected from alkyl, acyl, hydroxyalkyl and haloalkyl； each R is independently selected from hydrogen and alkyl； each R is independently selected from hydrogen, halo, alkyl, alkoxy and haloalkoxy, or two R in combination with the carbon atoms to which they are attached optionally substituted cycloalkyl is formed； each R is independently selected from halo, haloalkyl, haloalkoxy, alkyl, alkynyl, nitro, cyano, hydroxyl, —C (O) R, —OC (O) R, —C (O) OR, —SR, -NRR and -OR, or two R in combination with the carbon atoms to which they are attached form an optional Tel'nykh substituted heterocyclyl； n is 0, 1 or 2； m is 1, 2 or 3； h is 0, 1, 2； and g is 0, 1 or 2.2. The compound according to claim 1, characterized in that h = 1 and g = 1.3. The compound according to claim 2, characterized in that W, X, Y and Z are CH. 4. A compound according to claim 3, characterized in that D is NR and D is a bond. A compound according to claim 4, characterized in that R is H, methyl or ethyl. The compound according to claim 1, characterized in that L is a bond, - (CRR) -, -NRC (O) -, - (CRR) -C (O) -, -C (O) -, or -O (CO ) -. 7. A compound according to claim 6, characterized in that L is a bond. The compound according to claim 7, characterized in that R is alkyl1. Соединение формулы (I)или его фарма
