DILLON, Michael Patrick,JAHANGIR, Alam,LIN, Clara Jeou Jen
申请号：
ES06778314
公开号：
ES2562056T3
申请日:
2006.08.21
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I ** Formula ** or a pharmaceutically acceptable salt thereof, in which: X is -CH2-； -OR-； -They are-； or -NRc-, in which n is from 0 to 2 and Rc is hydrogen or alkyl； D is an optional oxygen； R1 is alkyl； alkenyl； alkynyl； cycloalkyl； cycloalkenyl； halo； haloalkyl； or hydroxyalkyl； R2, R3, R4 and R5 each is independently hydrogen； I rent； aminosulfonyl； alkenyl； halo； amido； haloalkyl； alkoxy； hydroxy； haloalkoxy； nitro； Not me； hydroxyalkyl； alkoxyalkyl； hydroxyalkoxy； alkylalkoxy； alkylsulfonyl； arylsulfonyl； cyano； aryl； heteroaryl； heterocyclyl； heterocyclylalkoxy； aryloxy； heteroaryloxy； aralkyloxy； heteroaralkyloxy； optionally substituted phenoxy； -C≡C-Ra； - (CH2) m- (Z) n- (CO) -Rb ；-( CH2) m- (Z) n-SO2- (NRc) n-Rb, in which each of myn is independently 0 or 1, Z is O or NRc, Ra is hydrogen； I rent； aryl； aralkyl； heteroaryl； heteroaralkyl； hydroxyalkyl； alkoxyalkyl； alkylsulfonylalkyl； aminoalkyl； cyanoalkyl； alkylsilyl, cycloalkyl, cycloalkylalkyl； heterocycle； and heterocyclylalkyl； Rb is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each Rc is independently hydrogen or alkyl； or R3 and R4 together with the atoms to which they are attached can form a five or six member ring that optionally includes one or two heteroatoms selected from O, S and N； or R2 and R3 together with the atoms to which they are attached may form a five or six member ring that optionally includes one or two heteroatoms selected from O, S and N； R6 is hydrogen； I rent； halo； haloalkyl； Not me； or alkoxy； and one of R7 and R8 is hydrogen and the other is R9, or both R7 and R8 are R9: each R9 is independently - (C>； = O) -Rd； - (O>； =) P (ORg) 2； -S (>； = O) 2ORg； or a mono-, di- or tri-peptide, in which Rd is alkyl, alkoxy, alkoxyalkyl, alkoxyalkoxyalkyl, alkylcarbonyloxyalkyl, amino, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, cycloalkyloxy, arylalkyloxy, arylalkyloxy, arylalkyl , hete
