POMPER MARTIN GILBERT,ПОМПЕР Мартин Гилберт,MIS RONNI CHARLZ,МИС Ронни Чарльз,CHEN IN,ЧЕН Ин
申请号：
RU2011107752/04
公开号：
RU0002494096C2
申请日:
2009.07.31
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention describes a prostate-specific membrane antigen (PSMA) compounds having a structure wherein Z represents tetrazolium or CO2Q each Q is independently specified in hydrogen or a protective group and wherein (A) m has a value of 0, 1, 2, 3, 4, 5 or 6 R represents a pyridine ring specified in a group including and wherein X represents fluorine, iodine, fluorine radioisotope, iodine radioisotope, chlorine, bromine, bromine radioisotope, astatine radioisotope, NO2, NH2, N+(R2)3, Sn(R2)3, Si(R2)3, Hg(R2), B(OH)2, -NHNH2, -NHN=CHR3, -NHNH-CH2R3 n has a value of 1, 2, 3, 4 or 5 Y represents O, S, N(R), C(O), NRC(O), C(O)N(R), OC(O), C(O)O, NRC(O)NR, NRC(S)NR, NRS(O)2, S(CH2)P, NR(CH2)p, O(CH2)p, OC(O)CHR8NHC(O), NHC(O)CHR8NHC(O) or a covalent bond wherein p has a value of 1, 2 or 3, R represents H or C1-C6 alkyl, and R8 represents hydrogen, alkyl, aryl or heteroaryl, each of which may be substituted R2 represents C1-C6 alkyl and R3 represents alkyl, alkenyl, alkinyl, aryl or heteroaryl each of which is substituted by fluorine, iodine, fluorine radioisotope, iodine radioisotope, chlorine, bromine, bromine radioisotope or astatine radioisotope NO2, NH2, N+(R2)3, Sn(R2)3, Si(R2)3, Hg(R2) or B(OH)2 or (B) m has a value of 0, 1, 2, 3, 4, 5 or 6 Y represents O, S, N(R), C(O), NRC(O), C(O)N(R), OC(O), C(O)O, NRC(O)NR, NRC(S)NR, NRS(O)2, S(CH2)P, NR(CH2)P, O(CH2)p, OC(O)CHR8NHC(O), NHC(O)CHR8NHC(O) or a covalent bond wherein p has a value of 1, 2 or 3, R represents H or C1-C6 alkyl, and R8 represents hydrogen, alkyl, aryl or heteroaryl, each of which may be substituted R represents wherein X is specified in a group including NHNH2, -NHN=CHR3 and -NHNH-CH2R3 wherein R3 represents alkyl, alkenyl, alkinyl, aryl or heteroaryl each of which is substituted by fluorine, iodine, fluorine radioisotope, iodine radioisotope, bromine, bromine radioisotope and astatine radioisotope NO2, NH2, N+(R2)3, Sn(R2)3, Si(R2)3, Hg(R) or B(OH)2 R2 repr
